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Details for Patent: 4,397,839

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Summary for Patent: 4,397,839

Title: Surface active material and process for preparing same
Abstract:A surface active material having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. This material comprises, based on the dry weight of the material, 68.6-90.7% of phospholipid, 0.3-13.0% of neutral fat, 0.0-8.0% of total cholesterol, 1.0-27.7% of free fatty acids, 0.1-2.0% of carbohydrate, and 0.0-3.5% of protein. The material is produced by subjecting mammalian lung tissue to a series of procedures including acetic acid ester treatment, organic solvent mixture treatment, differential centrifugation, density gradient centrifugation and dialysis, and optionally adding a phosphatidylcholine, a neutral fat, and/or a free fatty acid to the resulting product. A pharmaceutical composition comprising the surface active material is usable for the clinical treatment of respiratory distress syndrome.
Inventor(s): Tanaka; Yuji (Toda, JP)
Assignee: Tokyo Tanabe Company, Limited (JP)
Application Number:06/354,628
Patent Claim Types:
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Use; Composition; Formulation;

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Foreign Priority and PCT Information for Patent: 4,397,839

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan56-141672Sep 10, 1981

International Patent Family for Patent: 4,397,839

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
JapanS5845299► Subscribe
JapanS619924► Subscribe
Mexico9203492► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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