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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Queensland Health
Colorcon
US Department of Justice
Boehringer Ingelheim
Argus Health
Medtronic
Fuji
Moodys

Generated: April 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,396,597

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Summary for Patent: 4,396,597
Title: Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer
Abstract:Sterile, injectable, physiologically acceptable solutions of an X-ray contrast agent are prepared by autoclaving a solution of a m-carboxamido-o-iodo-N-(.beta.-hydroxyalkyl)aniline X-ray contrast agent in the presence of a physiologically acceptable buffer system the pH of which decreases with increasing temperature. The presence of a temperature dependent buffer, preferably an amine, enables X-ray contrast agents to be sterilized by autoclaving without significant decomposition. Examples of the autoclaving processes are given and solutions for autoclaving containing a m-carboxamido-o-iodo-N-(.beta.-hydroxyalkyl)aniline X-ray contrast agent and a physiologically acceptable buffer system the pH of which decreases with increasing temperature are described and claimed.
Inventor(s): Rakli; Fridtjov B. (Oslo, NO), Kelly; Michael J. (Oslo, NO)
Assignee: Nyegaard & Co. A/S (NO)
Application Number:06/233,137
Patent Claim Types:
see list of patent claims
Formulation; Compound; Process;

Drugs Protected by US Patent 4,396,597

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,396,597

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom28764/78Jul 4, 1978

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
McKinsey
UBS
Moodys
US Army
Fish and Richardson
Accenture
Mallinckrodt
Colorcon

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