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|Title:||Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation|
|Abstract:||A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen or C.sub.1-4 alkyl, R.sub.3 is isopropyl, sec.-butyl, isobutyl or benzyl, R.sub.4 is methyl, ethyl or isopropyl, and either R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy or R.sub.5 and R.sub.6 together is an additional bond, or mixtures thereof, dissolved in a pharmaceutically acceptable polar, hydrophilic soft gelatin capsule center fill solvent.|
|Inventor(s):||Stoopak; Samuel B. (West Caldwell, NJ), Kornblum; Saul S. (Springfield, NJ), Jacobs; Allen L. (Randolph, NJ)|
|Assignee:||Sandoz, Inc. (East Hanover, NJ)|
Patent Claim Types:|
see list of patent claims
|Use; Dosage form; Formulation;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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