Generated: December 18, 2017
DrugPatentWatch Database Preview
Details for Patent: 4,335,121
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Summary for Patent: 4,335,121
|Title:|| Androstane carbothioates|
|Abstract:||Compounds of the formula ##STR1## wherein R.sup.1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R.sup.2 represents a group COR.sup.6 where R.sup.6 is a C.sub.1-3 alkyl group or OR.sup.2 and R.sup.3 together form a 16.alpha.,17.alpha.-isopropylidenedioxy group; R.sup.3 represents a hydrogen atom, a methyl group (which may be in either the .alpha.- or .beta.-configuration) or a methylene group; R.sup.4 represents a hydrogen, chlorine or fluorine atom; R.sup.5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications. The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9.alpha.-halo-11.beta.-hydroxy grouping. Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.|
|Inventor(s):|| Phillipps; Gordon H. (Wembley, GB2), Bain; Brian M. (Chalfont St. Peter, GB2), Steeples; Ian P. (Ruislip Manor, GB2), Williamson; Christopher (Cobham, GB2) |
|Assignee:|| Glaxo Group Limited (London, GB2) |
Patent Claim Types:|
see list of patent claims
|Compound; Composition; Use; Process; |
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Foreign Priority and PCT Information for Patent: 4,335,121
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|United Kingdom||8005174||Feb 15, 1980|
International Patent Family for Patent: 4,335,121
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