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Generated: October 21, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,335,121

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Summary for Patent: 4,335,121

Title: Androstane carbothioates
Abstract:Compounds of the formula ##STR1## wherein R.sup.1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R.sup.2 represents a group COR.sup.6 where R.sup.6 is a C.sub.1-3 alkyl group or OR.sup.2 and R.sup.3 together form a 16.alpha.,17.alpha.-isopropylidenedioxy group; R.sup.3 represents a hydrogen atom, a methyl group (which may be in either the .alpha.- or .beta.-configuration) or a methylene group; R.sup.4 represents a hydrogen, chlorine or fluorine atom; R.sup.5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications. The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9.alpha.-halo-11.beta.-hydroxy grouping. Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.
Inventor(s): Phillipps; Gordon H. (Wembley, GB2), Bain; Brian M. (Chalfont St. Peter, GB2), Steeples; Ian P. (Ruislip Manor, GB2), Williamson; Christopher (Cobham, GB2)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:06/234,113
Patent Claim Types:
see list of patent claims
Compound; Composition; Use; Process;

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Foreign Priority and PCT Information for Patent: 4,335,121

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8005174Feb 15, 1980

International Patent Family for Patent: 4,335,121

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark147022► Subscribe
France2477156► Subscribe
Finland70904► Subscribe
Finland810444► Subscribe
Spain499394► Subscribe
EcuadorSP941097► Subscribe
Denmark62381► Subscribe
Germany3153379► Subscribe
Germany3105307► Subscribe
Czech Republic281275► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Express Scripts
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US Army
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