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Last Updated: March 19, 2024

Details for Patent: 3,950,529


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Summary for Patent: 3,950,529
Title: Amino acid formulations for patients with liver disease and method of using same
Abstract:Amino acid formulations for administration to human patients with liver disease comprise mixtures of essential amino acids combined in novel relative proportions, and preferably also include non-essential amino acids. In particular, the combined molar proportions of isoleucine, leucine, and valine are from 40 to 300 times the molar proportion of tryptophan and from 15 to 135 times the molar proportion of phenylalanine, or phenylalanine and tyrosine. The formulations may be adapted for either intravenous or oral administration, but the preferred method of administration is by hyperalimentation infusion. The formulations and method can be utilized to provide nutritional support for liver diseased patients while reducing the incidence and severity of hepatic encephalopathy, and/or as primary therapy for treatment of hepatic encephalopathy.
Inventor(s): Fischer; Josef E. (Boston, MA), Yoshimura; Norman N. (Woodland Hills, CA), Westman; Thomas L. (Northridge, CA), Deindoerfer; Fred H. (Northridge, CA)
Assignee: Massachusetts General Hospital (Boston, MA) American Hospital Supply Corporation (Evanston, IL)
Application Number:05/546,689
Patent Claim Types:
see list of patent claims
Formulation; Compound; Dosage form; Use;

Drugs Protected by US Patent 3,950,529

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 3,950,529

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 1024076 ⤷  Try a Trial
Belgium 838231 ⤷  Try a Trial
Canada 1050890 ⤷  Try a Trial
Germany 2556100 ⤷  Try a Trial
Denmark 579875 ⤷  Try a Trial
France 2299023 ⤷  Try a Trial
United Kingdom 1507951 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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