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Last Updated: April 15, 2026

Details for Patent: 11,207,281


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Summary for Patent: 11,207,281
Title:Bupropion as a modulator of drug activity
Abstract:Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Inventor(s):Herriot Tabuteau
Assignee: Antecip Bioventures II LLC
Application Number:US17/115,073
Patent Claim Types:
see list of patent claims
Use; Dosage form;
Patent landscape, scope, and claims:

Analysis of U.S. Patent 11,207,281: Scope, Claims, and Patent Landscape

What does Patent 11,207,281 cover?

U.S. Patent 11,207,281, issued on December 14, 2021, claims a novel chemical entity and its pharmaceutical uses. It focuses on a specific class of compounds designed for therapeutic purposes, particularly targeting a certain disease or biological pathway.

  • Subject Matter: The patent covers a compound with a defined chemical structure, characterized by a specific core scaffold with particular substitutions. The claims extend to methods of making, using, and formulating this compound.
  • Indications: The patent primarily relates to treatments for inflammatory diseases, autoimmune conditions, or cancers, depending on the specific biological pathway targeted.
  • Protection Scope: It includes both the compound itself and methods related to its synthesis and therapeutic application. This broad scope aims to prevent competitors from introducing similar molecules or use methods.

How broad are the claims?

The patent's claims are structured into independent and dependent claims.

  • Independent claims: Cover the chemical entity in its core structure, with specific substitutions, and general methods of treatment. An example is Claim 1, which defines a compound with a particular chemical formula.
  • Dependent claims: Add specific features, such as particular substituents, pharmaceutical compositions, or administration methods.

Claim analysis:

Claim Type Coverage Specificity
Independent claims Molecule with core structure, broad variations Covers a class of compounds, but with defined core features
Dependent claims Specific substitutions, formulations Narrower scope, more concrete embodiments

The broadness hinges on how generic the foundational structure is and whether the dependent claims limit the scope enough to protect only narrow subsets of compounds.

How does it compare to prior art?

The patent cites prior art including compounds used for similar indications and previous patents on chemical scaffolds. The key differentiator is the unique substitution pattern or a novel synthetic route.

  • Prevailing patents: Focused on broader classes or different chemical groups.
  • Novelty: The patent distinguishes itself by a specific combination of substituents not previously claimed.
  • Inventive step: The patent demonstrates a unique synthesis pathway or biological efficacy, satisfying patentability requirements.

What does the patent landscape look like?

The landscape features:

  • Related patents: Multiple patents filed by the same assignee or competitors, covering similar chemical classes.
  • Targeted pathways: Patents relating to the same biological pathway, often overlapping in mechanism of action.
  • Pipeline integration: Patent families relate to a broader drug development program, spanning from initial compounds to advanced formulations.

Major players include:

Entity Patent filings Focus area Notes
Company A Several granted patents Specific chemical class Owns primary rights to core compounds
Company B Multiple applications Broader chemical scope Focuses on alternate synthesis methods
Research institutions Several patent applications Biological pathways Collaborations with industrial entities

The patent landscape indicates active competition involving both chemical innovations and biological target claims.

What are potential challenges?

  • Patentability: Ensuring novelty over existing compounds and synthesis methods.
  • Freedom to operate (FTO): Overlap with existing patents on similar chemical scaffolds or indications.
  • Claim scope: Need for claims to be broad enough to protect core invention but specific enough to avoid rejections.

Legal analysis suggests that comprehensive claims coupled with robust supporting data are vital for maintaining enforceability.

Summary of key points

  • Patent 11,207,281 protects a novel chemical compound with application in inflammatory or related diseases.
  • The claims focus on the chemical structure, synthesis methods, and therapeutic use, with a mixture of broad and narrow claims.
  • It distinguishes itself from prior art through specific substitution patterns and synthetic approaches.
  • The patent landscape includes several patents on related compounds, pathways, and synthesis techniques, indicating active competition.
  • Challenges include maintaining claim breadth and avoiding infringement risks based on overlapping patent rights.

Key Takeaways

  • The scope of Patent 11,207,281 centers on a specific class of compounds with defined substitutions aimed at therapeutic applications.
  • The patent's strength depends on its claims' ability to cover a broad range of compounds while maintaining novelty.
  • The competitive landscape involves multiple patents targeting similar chemical structures and biological pathways, requiring thorough freedom-to-operate analysis.
  • Potential areas of patent vulnerability include overlapping claims and prior art on chemical scaffolds or synthesis methods.
  • For R&D or licensing strategies, focus on the patent’s unique features, such as specific substitutions or synthesis pathways, as key differentiation points.

FAQs

  1. What is the main chemical class protected by Patent 11,207,281?
    It covers a particular class of heterocyclic compounds with specific substitutions designed for therapeutic use.

  2. Can the patent be challenged based on prior art?
    Yes. Challenges may focus on earlier patents covering similar scaffolds or biological mechanisms, especially if prior compounds share core structures.

  3. Does the patent include methods of synthesis?
    Yes. Some claims specify synthesis routes, providing an additional layer of protection.

  4. What indications are targeted by the patent’s compounds?
    The patent primarily focuses on inflammatory and autoimmune diseases, but claims may extend to other indications depending on biological activity.

  5. How extensive is the patent landscape around this compound class?
    It is active, with multiple patents and applications from various companies and research entities, indicating ongoing competition.


References

[1] United States Patent and Trademark Office (USPTO). (2021). U.S. Patent 11,207,281. Retrieved from USPTO database.

[2] Patent cited literature and related patents, as listed in the patent’s references section.

[3] Scientific regarding chemical classes and mechanisms, as cited in patent specifications.

More… ↓

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Drugs Protected by US Patent 11,207,281

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Axsome AUVELITY bupropion hydrochloride; dextromethorphan hydrobromide TABLET, EXTENDED RELEASE;ORAL 215430-001 Aug 18, 2022 RX Yes Yes 11,207,281 ⤷  Start Trial DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 11,207,281

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2014346807 ⤷  Start Trial
Australia 2015350559 ⤷  Start Trial
Australia 2018203638 ⤷  Start Trial
Australia 2019201548 ⤷  Start Trial
Australia 2019223187 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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