United States Patent 11,142,528: A Detailed Analysis of Scope, Claims, and Patent Landscape
Introduction
United States Patent 11,142,528, titled "Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators," is a significant patent in the pharmaceutical industry, particularly in the field of immunology and oncology. This patent, granted to a pharmaceutical company, outlines novel compounds and their use in treating various diseases.
Background
Bruton's tyrosine kinase (Btk) is a key enzyme in the B-cell receptor signaling pathway, making it a target for treating B-cell-related diseases such as lymphomas, autoimmune disorders, and certain types of leukemia. The patent in question describes a class of substituted pyrazolo[1,5-a]pyrimidines that act as Btk modulators.
Scope of the Patent
The scope of US Patent 11,142,528 is broad and encompasses several key aspects:
Chemical Compounds
The patent describes a series of substituted pyrazolo[1,5-a]pyrimidine compounds, each with specific structural modifications. These compounds are designed to inhibit Btk activity, thereby modulating the immune response[4].
Therapeutic Uses
The patent outlines the therapeutic applications of these compounds, including the treatment of B-cell-related cancers, autoimmune diseases, and inflammatory disorders. The compounds are intended to provide a more targeted and effective treatment option compared to existing therapies[4].
Synthesis Methods
The patent also details the methods for synthesizing these compounds, which is crucial for their production and scalability. This includes various chemical reactions and processes to obtain the desired pyrazolo[1,5-a]pyrimidine structures[4].
Claims of the Patent
The claims section of the patent is critical as it defines the legal boundaries of the invention. Here are some key claims:
Independent Claims
- Claim 1 typically defines the broadest scope of the invention, describing the general structure of the substituted pyrazolo[1,5-a]pyrimidine compounds.
- Subsequent claims narrow down the scope by specifying particular substituents, functional groups, and their positions on the pyrazolo[1,5-a]pyrimidine core[4].
Dependent Claims
- These claims build upon the independent claims, adding additional limitations or specific features to the compounds. For example, claims might specify certain aryl or heteroaryl groups, cycloalkyl substituents, or specific chemical moieties[4].
Patent Landscape
Understanding the patent landscape is essential for navigating the intellectual property environment surrounding Btk modulators.
Prior Art
The patent cites several prior art references, including earlier patents and publications related to Btk inhibitors and pyrazolo[1,5-a]pyrimidine compounds. This section helps in distinguishing the current invention from existing knowledge in the field[4].
International Patent Offices
The patent is part of a global patent family, with corresponding applications filed in various international patent offices such as the European Patent Office (EPO), Japan Patent Office (JPO), and the World Intellectual Property Organization (WIPO)[1].
Related Patents and Applications
There are other patents and patent applications related to Btk modulators and similar chemical compounds. These include patents from other pharmaceutical companies and research institutions, which together form a complex patent landscape in this therapeutic area[1][4].
Search and Analysis Tools
For a comprehensive analysis of this patent and its place in the broader patent landscape, several tools and resources are available:
USPTO Patent Public Search
The USPTO's Patent Public Search tool allows users to search for prior art, including patents and published patent applications. This tool is crucial for conducting a thorough search to ensure the novelty and non-obviousness of the invention[1].
Global Dossier
The Global Dossier service provides access to the file histories of related applications from participating IP offices, helping to identify the patent family and related applications globally[1].
Common Citation Document (CCD)
The CCD application consolidates citation data from multiple patent offices, enabling a single-point access to prior art citations for the patent family. This is particularly useful for understanding the international patent landscape[1].
Economic and Research Implications
The Patent Claims Research Dataset provided by the USPTO can offer insights into the scope and trends of patent claims, including those related to pharmaceutical inventions. This dataset can help in analyzing the patent scope measurements and trends over time[3].
Key Takeaways
- Novel Compounds: The patent introduces novel substituted pyrazolo[1,5-a]pyrimidine compounds as Btk modulators.
- Therapeutic Applications: These compounds are intended for treating B-cell-related cancers and autoimmune diseases.
- Synthesis Methods: Detailed methods for synthesizing these compounds are provided.
- Patent Claims: The patent includes broad and narrow claims defining the scope of the invention.
- Global Patent Landscape: The patent is part of a global patent family with corresponding applications in various international patent offices.
FAQs
What is the main subject of United States Patent 11,142,528?
The main subject of this patent is the description and use of substituted pyrazolo[1,5-a]pyrimidine compounds as Bruton's tyrosine kinase modulators.
What are the therapeutic applications of the compounds described in this patent?
The compounds are intended for treating B-cell-related cancers, autoimmune diseases, and inflammatory disorders.
How can one search for related patents and prior art?
One can use the USPTO's Patent Public Search tool, Global Dossier service, and the Common Citation Document (CCD) application to search for related patents and prior art.
What is the significance of the claims section in this patent?
The claims section defines the legal boundaries of the invention, distinguishing it from existing knowledge and prior art.
Where can one find detailed information on the synthesis methods for these compounds?
The patent document itself provides detailed methods for synthesizing the substituted pyrazolo[1,5-a]pyrimidine compounds.
Sources
- USPTO - Search for patents: https://www.uspto.gov/patents/search
- DrugPatentWatch - Patent 11,142,528: https://www.drugpatentwatch.com/p/patent/11142528
- USPTO - Patent Claims Research Dataset: https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
- Google Patents - US11142528B2: https://patents.google.com/patent/US11142528B2/en
