Last Updated: September 24, 2026

Details for Patent: 10,849,916


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Which drugs does patent 10,849,916 protect, and when does it expire?

Patent 10,849,916 protects FRINDOVYX and is included in one NDA.

This patent has one patent family member in one country.

Summary for Patent: 10,849,916
Title:Stable liquid formulations of cyclophosphamide and its impurities
Abstract:The present invention relates to novel impurities of cyclophosphamide having structure V, VI or VII, stabilized form of these novel impurities, a process of preparing a stabilized form and isolating thereof. The invention also relates cyclophosphamide formulations which include cyclophosphamide, at least one pharmaceutically acceptable excipient, and a certain level of these impurities having structure V, VI or VII. The invention further relate to method of using such stable liquid formulations of cyclophosphamide for parenteral administration in treating various cancer disorders.
Inventor(s):Riyaz Ahmed Shaik, Ananya SAHA, SVB Janardhan Garikipati, Akash CHAURASIYA, Bhavesh Vallabhbhai PATEL, Harshal BHAGWATWAR, Sumitra Ashok Pillai, Satheesh Balasubramanian, Joydeep MAZUMDER
Assignee: Avyxa Holdings LLC
Application Number:US16/414,418
Patent Claim Types:
see list of patent claims
Composition; Formulation; Compound;

Drugs Protected by US Patent 10,849,916

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Avyxa Holdings FRINDOVYX cyclophosphamide SOLUTION;INTRAVENOUS 210852-002 Jun 7, 2023 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Avyxa Holdings FRINDOVYX cyclophosphamide SOLUTION;INTRAVENOUS 210852-003 Jun 7, 2023 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Avyxa Holdings FRINDOVYX cyclophosphamide SOLUTION;INTRAVENOUS 210852-001 Jun 7, 2023 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 10,849,916

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
World Intellectual Property Organization (WIPO) 2016005962 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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