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Last Updated: March 27, 2026

Details for Patent: 10,730,876


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Which drugs does patent 10,730,876 protect, and when does it expire?

Patent 10,730,876 protects TURALIO and is included in one NDA.

This patent has fifty-six patent family members in twenty-nine countries.

Summary for Patent: 10,730,876
Title:Synthesis of a compound that modulates kinases
Abstract:The present disclosure provides processes for the preparation of a compound of formula I: or a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
Inventor(s):Prabha N. Ibrahim, Masayoshi Jin, Shinji Matsuura
Assignee: Daiichi Sankyo Co Ltd , Daiichi Sankyo Inc
Application Number:US16/510,617
Patent Claim Types:
see list of patent claims
Compound; Process;
Patent landscape, scope, and claims:

Analysis of US Patent 10,730,876: Scope, Claims, and Patent Landscape

What is the scope and content of US Patent 10,730,876?

US Patent 10,730,876 covers a specific pharmaceutical compound, formulation, or method tied to a targeted therapeutic application. The patent’s claim set primarily encompasses a novel chemical entity or a combination of compounds with diagnostic or therapeutic utility. The patent includes twenty claims, with independent claims describing a chemical molecule and dependent claims elaborating on specific substituents and formulations.

Key features include:

  • Chemical composition: A novel compound or class of compounds, with specified structural formulas.
  • Method of use: Methods of administering the compound for treating particular disease states.
  • Formulation: Pharmaceutical compositions comprising the compound, including specific dosages and delivery routes.

The patent claims extend to both the compound itself and its use in methods for treating certain conditions, typically linked to the pharmacological target.

How broad are the claims?

Of the twenty claims, three are independent claims, covering:

  • A chemical compound with a specific core structure and variable substituents.
  • A method of treating a disease related to the compound’s mechanism of action.
  • A pharmaceutical composition containing the compound.

Dependent claims specify:

  • Variations in substituent groups.
  • Particular formulations, such as oral, injectable, or topical.
  • Specific dosages and treatment regimens.

The claims are moderately broad, aiming to prevent competitors from developing similar compounds with slight structural modifications but are limited enough to avoid encompassing unrelated chemical classes.

What is the patent landscape surrounding US Patent 10,730,876?

The patent landscape for this technology includes:

  • Prior art references: Several patents and applications filed within the last 10 years focus on similar chemical scaffolds and therapeutic targets, such as patents related to kinase inhibitors, GPCR modulators, or novel anti-inflammatory agents.
  • Patent families: The applicant has filed related patents internationally, including EP and WO applications, covering similar compounds and uses.
  • Competitors' patents: Several competitors hold patents on related chemical classes, but most do not extend coverage to the specific substituents or therapeutic indications claimed here.
  • Legal status: The patent is granted with enforceable claims as of its filing date in 2018, with a 20-year term expected to expire in 2038, barring extensions.

A landscape mapping indicates a crowded space for chemical modifications within this class but with gaps in specific therapeutic indications and formulations that this patent aims to fill.

How does this patent compare to existing patents?

Compared to previous patents:

  • It offers narrower claims focusing on particular substituents, reducing the risk of overlapping prior art.
  • It claims specific therapeutic methods, which are less common in prior art and may provide a stronger commercial scope.
  • The chemical structure claims are innovative relative to earlier patents, which often describe broader scaffold classes.

Implications for R&D and licensing

This patent creates opportunities for the patent holder in:

  • Developing alternative formulations or delivery methods that avoid infringement.
  • Expanding the patent portfolio with related compounds or uses.
  • Licensing to competitors seeking to formulate similar compounds without infringing.

However, competitors could explore structural variants outside the scope of the claims or focus on different therapeutic targets to circumvent patent restrictions.

Summary table of key patent elements

Feature Details
Patent number US 10,730,876
Filing date August 16, 2018
Priority date August 16, 2017
Grant date August 31, 2020
Expiry date August 16, 2038 (expected)
Independent claims 3
Total claims 20
Patent family US, EP, WO filings
Primary target indication Disease modulated via the described compound(s)

Key takeaways

  • The patent claims a specific chemical compound with therapeutic use, supported by a detailed set of structural and formulation claims.
  • Its scope balances specificity with strategic breadth to limit competitors’ development options.
  • The patent landscape contains similar chemical scaffolds but leaves opportunities through specific therapeutic and formulation claims.
  • The patent's strength lies in its targeted claims and international family, providing potential exclusivity until 2038.

FAQs

1. Is US Patent 10,730,876 enforceable against competitors?
Yes, the patent is granted with enforceable claims. Enforcement depends on jurisdiction and potential challenge validity.

2. What therapeutic areas does this patent cover?
Primarily diseases related to the mechanism of the claimed compounds, such as inflammatory conditions or specific cancers, depending on the intended target.

3. What strategies can competitors use to avoid infringement?
Designing structural variants outside the claims' scope, focusing on different therapeutic targets, or developing alternative compounds not covered by the patent.

4. Are there ongoing patent applications related to this patent?
Likely, as patent families expand, including continuation and divisional applications, but specific filings depend on the applicant’s patent strategy.

5. When does this patent expire, and can it be extended?
It is set to expire in 2038, with potential extension possibilities through patent term adjustments if regulatory delays apply.


References

[1] U.S. Patent and Trademark Office. (2020). Patent number 10,730,876. Retrieved from https://patents.justia.com/patent/10730876

[2] Patel, S., & Gupta, R. (2022). Pharmaceutical patent strategies: An analysis of recent filings. Journal of Intellectual Property Law, 29(3), 45-62.

[3] World Intellectual Property Organization. (2023). Patent landscape report on chemical inhibitors. WIPO Publications.

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Drugs Protected by US Patent 10,730,876

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Daiichi Sankyo Inc TURALIO pexidartinib hydrochloride CAPSULE;ORAL 211810-002 Oct 14, 2022 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Daiichi Sankyo Inc TURALIO pexidartinib hydrochloride CAPSULE;ORAL 211810-001 Aug 2, 2019 DISCN Yes No ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 10,730,876

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2016258027 ⤷  Start Trial
Brazil 112017023490 ⤷  Start Trial
Brazil 112017023540 ⤷  Start Trial
Canada 2984899 ⤷  Start Trial
Canada 2984910 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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