Details for Patent: 10,125,149
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Which drugs does patent 10,125,149 protect, and when does it expire?
Patent 10,125,149 protects ZERBAXA and is included in one NDA.
This patent has four patent family members in three countries.
Summary for Patent: 10,125,149
| Title: | Synthesis of cephalosporin compounds |
| Abstract: | Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof. |
| Inventor(s): | Waller; David (Somerville, MA), Gazda; Gregory (Sudbury, MA), Minden; Zachary (Watsonville, CA), Barton; Lisa (Haverhill, MA), Leigh; Clifton (Windham, NH) |
| Assignee: | Merck Sharp & Dohme Corp. (Rahway, NJ) |
| Application Number: | 15/503,907 |
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Patent Claim Types: see list of patent claims | Composition; Compound; |
Drugs Protected by US Patent 10,125,149
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cubist Pharms Llc | ZERBAXA | ceftolozane sulfate; tazobactam sodium | POWDER;INTRAVENOUS | 206829-001 | Dec 19, 2014 | RX | Yes | Yes | ⤷ Try a Trial | ⤷ Try a Trial | Y | ⤷ Try a Trial | ||||
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 10,125,149
| PCT Information | |||
| PCT Filed | August 14, 2015 | PCT Application Number: | PCT/US2015/045287 |
| PCT Publication Date: | February 18, 2016 | PCT Publication Number: | WO2016/025839 |
International Family Members for US Patent 10,125,149
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| China | 106795175 | ⤷ Try a Trial | |||
| China | 110204558 | ⤷ Try a Trial | |||
| European Patent Office | 3180347 | ⤷ Try a Trial | |||
| World Intellectual Property Organization (WIPO) | 2016025839 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
