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|Title:||5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2|
|Abstract:||The Compound of Formula I and pharmaceutically acceptable sales thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed. ##STR1##|
|Inventor(s):||Guay; Daniel (Ile Perrot, CA), Li; Chun-Sing (Dollard des Ormeaux, CA)|
|Assignee:||Merck Frosst Canada & Co. (Rairkland, CA)|
|Filing Date:||Apr 06, 2001|
|Claims:||1. A compound of the formula I ##STR37## |
or a pharmaceutically acceptable salt thereof.
2. A method of selectively inhibiting cyclooxygenase-2 comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to claim 1.
3. A method of treating a cyclooxygenase-2 mediated disease in patients having a history of a gastro-intestinal disorder comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to claim 1..[.
4. A method of selectively inhibiting cyclooxygenase-2 comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to claim 1..]..Iadd.
5. A method for selectively inhibiting cyclooxygenase-2activity in a human host, comprising administering a non-steroidal compound that selectively inhibits activity of the cyclooxygenase-2 gene product to a human host in need of such treatment, wherein said non-steroidal compound is a compound of the formula I ##STR38##
or a pharmaceutically acceptable salt thereof..Iaddend..Iadd.
6. The method of claim 5, wherein the compound of formula I is administered at a dosage of from about 0.01 mg to about 140 mg per kilogram of body weight per day..Iaddend..Iadd.
7. The method of claim 5, wherein the compound of formula I is administered in an amount from about 1 mg to about 1000 mg..Iaddend.
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