.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: RE30241

« Back to Dashboard

Details for Patent: RE30241

Title: Esters of 3-(hydroxy or hydroxymethyl)-4-hydroxyphenyl aminomethyl ketones
Abstract:Mono-, di- and tri-esters of 3-(hydroxy or hydroxymethyl)-4-hydroxy-alpha-(aminomethyl)benzyl alcohols, obtained by methods involving reduction of the corresponding mono- and di-ester ketones, are useful for producing sympathomimetic effects, such as bronchodilation, of long duration with low cardiovascular stimulating effect, in warm-blooded mammals.
Inventor(s): Minatoya; Hiroaki (East Greenbush, NY), Tullar; Benjamin F. (Laurel Park, NC), Conway; Walter D. (Amherst, NY)
Assignee: Sterling Drug Inc. (New York, NY)
Filing Date:Jun 20, 1977
Application Number:05/808,280
Claims:1. A compound of the group consisting of: 3-(Y.sup.1 -O-)-4-(Y-O-)phenyl (R-NH-)(R')methyl ketones having the formula ##STR6## and 3-(Y-O-CH.sub.2 -)-4-(Y.sup.1 -O-)phenyl (R-NH-) (R')methyl ketones having the formula ##STR7## .Iadd.wherein R, in Formula III, is tert-butyl or cycloalkyl having 3-6 carbon atoms; and in Formula IV is hydrogen, alkyl having 1-4 carbon atoms, or cycloalkyl having 3-6 carbon atoms; and .Iaddend.

wherein, in each formula:

.[.R is hydrogen, alkyl having 1-4 carbon atoms, or cycloalkyl having 3-6 carbon atoms;.].

R' is hydrogen or alkyl having 1-3 carbon atoms;

Y' is hydrogen or an acyl member which is alkanoyl having 1-22 carbon atoms, cycloalkyl-C.sub.n H.sub.2n --CO-- having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, 1- or 2-adamantanecarbonyl, phenoxyacetyl, naphthalenecarbonyl, or Z--C.sub.n H.sub.2n --CO-- wherein n is zero, one or two and Z is phenyl or phenyl substituted by 1-3 members of the group consisting of alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, or trifluoromethyl;

Y is one of the acyl members defined by Y.sup.1, at least one of Y and Y.sup.1 being Z--C.sub.n H.sub.2n --CO--; and

.[.wherein in Formula III at least one of Y and Y.sup.1 contains no less than four carbon atoms when R is tert-butyl or cycloalkyl and no less than seven carbon atoms when R is hydrogen or alkyl other than tert-butyl; and in Formula IV at least one of Y and Y.sup.1 contains no less than four carbon atoms; and.]. acid-addition salts thereof.

2. A 3-(Y.sup.1 -O-)-4-(Y-O)phenyl(R-NH-)(R')methyl ketone according to claim 1.

3. A compound according to claim 2 wherein R' is hydrogen. .[.4. A compound

according to claim 3 wherein R is alkyl..]. 5. A compound according to

claim .[.4.]. .Iadd.3 .Iaddend.wherein R is tert-butyl. 6. A 3-(Y-O-CH.sub.2 -)-4-(Y.sup.1 -O-)phenyl (R-NH-) (R')methyl ketone

according to claim 1. 7. A compound according to claim 6 wherein R' is

hydrogen. 8. A compound according to claim 7 wherein R is alkyl. 9. A

compound according to claim 8 wherein R is tert-butyl. 10. A compound

according to claim 9 wherein one of Y and Y.sup.1 is alkanoyl. 11. A

compound according to claim 9 wherein Y.sup.1 is hydrogen. 12. A compound according to claim 5 wherein each of Y and Y.sup.1 is Z-C.sub.n H.sub.2n

--CO--. 13. A compound according to claim 12 wherein n is zero. 14. A compound according to claim 13 wherein each of Y and Y.sup.1 is

alkylbenzoyl. 15. A compound according to claim 14 wherein each of Y and

Y.sup.1 is toluyl. 16. A compound according to claim 13 wherein each of Y

and Y.sup.1 is anisoyl. 17. A compound according to claim 5 wherein one of

Y and Y.sup.1 is alkanoyl and the other is Z--C.sub.n H --CO--. 18. A

compound according to claim 17 wherein n is zero. 19. A compound according

to claim 18 wherein one of Y and Y.sup.1 is alkylbenzoyl. 20. A compound

according to claim 19 wherein one of Y and Y.sup.1 is toluyl. 21. A compound according to claim 18 wherein one of Y and Y.sup.1 is anisoyl.

A compound according to claim 5 wherein Y.sup.1 is hydrogen. 23. A

compound according to claim 22 wherein n is zero. 24. A compound according

to claim 23 wherein Y is toluyl. 25. A compound according to claim 23

wherein Y is anisoyl. 26. A compound according to claim 9 wherein each of

Y and Y.sup.1 is Z--C.sub.n H.sub.2n --CO--. 27. A compound according to claim 26 wherein n is zero.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc