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Generated: April 21, 2018

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Details for Patent: 9,676,797

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Title:Anti-viral compounds
Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
Inventor(s): Chen; Hui-Ju J. (Grayslake, IL), DeGoey; David A. (Salem, WI), Hartung; John (Evanston, IL), Ide; Nathan (Lindenhurst, IL), Kalthod; Vikram (North Chicago, IL), Krueger; Allan C. (Gurnee, IL), Ku; Yi-Yin (Buffalo Grove, IL), Li; Tongmei (Lake Bluff, IL), Randolph; John T. (Libertyville, IL), Wagner; Rolf (Antioch, IL), Chau; Jaclyn (Vancouver, CA), Halvorsen; Geoff T. (Lake Bluff, IL), Marvin; Christopher C. (Grayslake, IL), Voight; Eric (Pleasant Prairie, WI)
Assignee: AbbVie Inc. (North Chicago, IL)
Filing Date:Sep 01, 2016
Application Number:15/254,342
Claims:1. (S)-isopropyl 2-(((S)-(((2R,3R,4S,5R)-4-bromo-5-(2,4-dioxo-3,4-dihydropyrimidin-1 (2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphor- yl)amino)propanoate, or a pharmaceutically acceptable salt thereof.

2. Ethyl 2-(((((2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxo-3,4-dihydropyr- imidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl- )amino)-2-methylpropanoate, or a pharmaceutically acceptable salt thereof.

3. Ethyl 2-(((R)-(((2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxo-3,4-dihydr- opyrimidin-1 (2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)- -2-methylpropanoate, or a pharmaceutically acceptable salt thereof.

4. Ethyl 2-(((S)-(((2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxo-3,4-dihydr- opyrimidin-1 (2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)- -2-methylpropanoate, or a pharmaceutically acceptable salt thereof.

5. Ethyl 2-(((S)-(((2R,3R,4S,5R)-4-bromo-5-(2,4-dioxo-3,4-dihydropyrimidi- n-1 (2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosp- horyl)amino)-2-methylpropanoate, or a pharmaceutically acceptable salt thereof.

6. A method for treating HCV, comprising administering a compound or salt of claim 1 to an HCV patient.

7. A method for treating HCV, comprising administering a compound or salt of claim 2 to an HCV patient.

8. A method for treating HCV, comprising administering a compound or salt of claim 3 to an HCV patient.

9. A method for treating HCV, comprising administering a compound or salt of claim 4 to an HCV patient.

10. A method for treating HCV, comprising administering a compound or salt of claim 5 to an HCV patient.

11. A pharmaceutical composition comprising a compound or salt of claim 1.

12. A pharmaceutical composition comprising a compound or salt of claim 2.

13. A pharmaceutical composition comprising a compound or salt of claim 3.

14. A pharmaceutical composition comprising a compound or salt of claim 4.

15. A pharmaceutical composition comprising a compound or salt of claim 5.

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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
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Harvard Business School

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