Details for Patent: 9,656,999
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Title: | Therapeutically active compounds and their methods of use |
Abstract: | Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein. |
Inventor(s): | Cianchetta; Giovanni (Waltham, MA), DeLaBarre; Byron (Arlington, MA), Popovici-Muller; Janeta (Waltham, MA), Salituro; Francesco G. (Marlborough, MA), Saunders; Jeffrey O. (Lincoln, MA), Travins; Jeremy (Southborough, MA), Yan; Shunqi (Irvine, CA), Guo; Tao (Dayton, NJ), Zhang; Li (Shanghai, CN) |
Assignee: | Agios Pharmaceuticals, Inc. (Cambridge, MA) |
Filing Date: | Oct 28, 2016 |
Application Number: | 15/337,683 |
Claims: | 1. A method of synthesizing ##STR01112## comprising reacting 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2- -methylpropan-2-ol with 2-trifluoromethylpyridin-4-ylamine in the presence of sodium tert-butoxide and Pd(dppf)Cl.sub.2. 2. The method of claim 1, wherein the 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2- -methylpropan-2-ol is synthesized by a method comprising reacting 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine with 2-hydroxy-2-methyl-1-propylamine. 3. The method of claim 2, wherein the 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine is synthesized by a method comprising reacting 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione with POCl.sub.3 and PCl.sub.5. 4. The method of claim 3, wherein the 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione is synthesized by a method comprising reacting 6-trifluoromethylpyridine-2-carboxylic acid methyl ester with biuret in the presence of Na in ethanol. |