Details for Patent: 9,629,828

Title:	Methods of treating traveler's diarrhea and hepatic encephalopathy
Abstract:	Treatment of traveler's diarrhea using in subjects having hepatic encephalopathy using gastrointestinal specific antibiotics is disclosed. One example of a gastrointestinal specific antibiotic is rifaximin.
Inventor(s):	Forbes; William (Raleigh, NC), Bortey; Enoch (Chapel Hill, NC)
Assignee:	Salix Pharmaceuticals, Ltd. (Bridgewater, NJ)
Filing Date:	Jan 26, 2015
Application Number:	14/605,109
Claims:	1. A method of reducing the risk of overt hepatic encephalopathy (HE) recurrence in a subject comprising: identifying a subject having TD that also has chronic liver disease; and administering between 1000 and 1200 mg of rifaximin daily to the subject, wherein the subject is in remission from HE and had two or more episodes of HE associated with chronic liver disease in the 6-month period prior to administration. 2. The method of claim 1, wherein the subject is administered 1100 mg of rifaximin. 3. The method of claim 2, wherein the subject is administered 550 mg of rifaximin tow times per day (BID). 4. The method of claim 1, wherein the subject is a human. 5. The method of claim 1, wherein the rifaximin comprises tablets for oral administration comprising one or more of colloidal silicon dioxide, disodium edetate, glycerol palmitostearate, hypromellose, microcrystalline cellulose, propylene glycol, red iron oxide, sodium starch glycolate, talc, or titanium dioxide. 6. The method of claim 1, comprising administering 1100 mg of rifaximin per day to a patient for more than 28 days. 7. The method of claim 6, comprising administering rifaximin to the subject for 6 months or longer. 8. The method of claim 7, comprising administering rifaximin to the subject for 1 year or longer. 9. The method of claim 1, wherein the chronic liver disease is cirrhosis. 10. The method of claim 1, further comprising determining if the subject's Child-Pugh score is Child-Pugh Class A; and administering between 1000 and 1200 mg of rifaximin daily to the subject if his or her Child-Pugh score is Child-Pugh Class A. 11. The method of claim 1, further comprising determining if the subject's Child-Pugh score is Child-Pugh Class B; and administering between 1000 and 1200 mg of rifaximin daily to the subject if his or her Child-Pugh score is Child-Pugh Class B. 12. The method of claim 1, further comprising determining if the subject's Child-Pugh score is Child-Pugh Class C; and administering between 1000 and 1200 mg of rifaximin daily to the subject if his or her Child-Pugh score is Child-Pugh Class C.