Details for Patent: 9,545,457

Title:	Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
Abstract:	The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
Inventor(s):	Hui; Poh K. (Wellesley Hills, MA), Bishop; John E. (Groton, MA), Madrigal, Jr.; Eleodoro S. (Westford, MA)
Assignee:	Lantheus Medical Imaging, Inc. (North Billerica, MA)
Filing Date:	Feb 24, 2014
Application Number:	14/188,598
Claims:	1. A method comprising using an ultrasound contrast agent to enhance contrast in an echocardiographic ultrasound image of a subject, wherein the ultrasound contrast agent comprises 1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL; sodium chloride; glycerin, present in an amount of about 0.1 mL/mL; propylene glycol, present in an amount of about 0.1 mL/mL; water, and perfluoropropane.