Details for Patent: 9,447,077
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Title: | Crystalline pharmaceutical and methods of preparation and use thereof |
Abstract: | Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. ##STR00001## |
Inventor(s): | Burnier; John (Pacifica, CA), Gadek; Thomas (Oakland, CA), Naud; Frederic (Binningen, CH) |
Assignee: | SARcode Bioscience Inc. (Brisbane, CA) |
Filing Date: | Sep 19, 2014 |
Application Number: | 14/491,333 |
Claims: | 1. A method of treating dry eye disease in a subject in need of such treatment, the method comprising administering to the subject an effective amount of a composition comprising an isolated compound of Formula I: ##STR00028## or a pharmaceutically acceptable salt thereof, wherein said compound comprises a purity of greater than about 90%. 2. The method of claim 1, wherein said compound has a purity of greater than about 98%. 3. The method of claim 1, wherein said compound comprises at least about 95% of an S-enantiomer. 4. The composition of claim 1, wherein said compound is a sodium salt. |