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|Title:||Method of forming an aerosol for inhalation delivery|
|Abstract:||The present application relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition of a drug to form a vapor, wherein the coated composition is in the form of a film less than 10.mu. thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method involves: (a) heating a substrate coated with a composition of a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.|
|Inventor(s):||Hale; Ron L. (Sandia Park, NM), Hodges; Craig C. (Walnut Creek, CA), Lloyd; Peter M. (Walnut Creek, CA), Mufson; Daniel (Napa, CA), Rogers; Daniel D. (Oakland, CA), Song; Soonho (Seoul, KR), Wensley; Martin J. (Los Gatos, CA), Myers; Daniel J. (Mountain View, CA), McKinney; Jeffrey A. (Lafayette, CA), Quintana; Reynaldo J. (Menlo Park, CA), Rabinowitz; Joshua D. (Princeton, NJ)|
|Assignee:||ALEXZA PHARMACEUTICAL, INC. (Mountain View, CA)|
|Filing Date:||Nov 11, 2013|
|Claims:||1. A method of forming an aerosol comprising loxapine, said method comprising: (a) heating a substrate coated with a composition comprising loxapine for a period of time by a heater system, thereby forming a vapor, wherein the period of time is less than 500 milliseconds and wherein an increase in temperature of the substrate over the period of time is greater than 1000.degree. C./s; and (b) allowing the vapor to cool, thereby forming an aerosol comprising loxapine. |
2. An apparatus, comprising: a housing defining an airway extending between an inlet of the housing and an outlet of the housing, a first portion of the airway having a first cross-sectional area, a second portion of the airway having a second cross-sectional area less than the first cross-sectional area, the second portion of the airway; and a substrate, at least a portion of the substrate having a surface in communication with the second portion of the airway, the portion of the substrate configured to be heated by a heater system such that a composition comprising loxapine coated on the surface of the substrate is engaged by air passing through the airway upon inhalation by a patient, the heater system configured to heat the composition to a vaporization temperature to begin vaporization of the composition and forming a vaporized composition, the second portion of the airway configured to increase a speed of the air passing over the surface of the composition to remove vapors resulting from vaporization of the composition from the heated portion of the substrate, the second portion of the airway configured to cool the removed vapors below the vaporization temperature without significant decomposition of the vaporized composition.
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