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Last Updated: March 28, 2024

Details for Patent: 9,434,717


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Title:Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl) benzoic acid
Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
Inventor(s): Keshavarz-Shokri; Ali (San Diego, CA), Zhang; Beili (San Diego, CA), Krawiec; Mariusz (Marlborough, MA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Filing Date:Aug 31, 2015
Application Number:14/841,163
Claims:1. A process for preparing 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid characterized as Form I, comprising suspending or dissolving the HCl salt of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid in an appropriate solvent for an effective amount of time.

2. The process of claim 1, wherein the appropriate solvent is water or 50% methanol/water mixture.

3. The process of claim 1, wherein the appropriate solvent is water.

4. The process of claim 1, wherein the effective amount of time is 2 to 24 hours.

5. The process of claim 1, wherein the effective amount of time is 2 to 6 hours.

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