Details for Patent: 9,434,717
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Title: | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl) benzoic acid |
Abstract: | The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith. |
Inventor(s): | Keshavarz-Shokri; Ali (San Diego, CA), Zhang; Beili (San Diego, CA), Krawiec; Mariusz (Marlborough, MA) |
Assignee: | Vertex Pharmaceuticals Incorporated (Boston, MA) |
Filing Date: | Aug 31, 2015 |
Application Number: | 14/841,163 |
Claims: | 1. A process for preparing 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid characterized as Form I, comprising suspending or dissolving the HCl salt of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic acid in an appropriate solvent for an effective amount of time. 2. The process of claim 1, wherein the appropriate solvent is water or 50% methanol/water mixture. 3. The process of claim 1, wherein the appropriate solvent is water. 4. The process of claim 1, wherein the effective amount of time is 2 to 24 hours. 5. The process of claim 1, wherein the effective amount of time is 2 to 6 hours. |