Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Medtronic
Harvard Business School
Federal Trade Commission
Boehringer Ingelheim
Novartis
Farmers Insurance
McKesson
Fish and Richardson
Fuji

Generated: October 22, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Effervescent compositions containing N-acetylcysteine
Abstract: Effervescent pharmaceutical compositions containing a high amount of N-acetylcysteine and a method of treating acetaminophen poisoning with effervescent pharmaceutical compositions containing a high amount of N-acetylcysteine are described.
Inventor(s): Stroppolo; Federico (Aldesago, CH), Granata; Gabriele (Leggiuno, IT), Ardalan; Shahbaz S. (Massagno, CH)
Assignee: ALPEX PHARMA S.A. (Mezzovico, CH)
Filing Date:Jul 15, 2015
Application Number:14/800,228
Claims:1. An oral effervescent composition comprising at least 50% w/w of N-acetylcysteine, at least 20% w/w of a carbonate or bicarbonate salt, without an additional organic or inorganic acid, and from 3.5% to 15% w/w of a mixture of pharmaceutically acceptable excipients comprising a sweetener, a flavorant, and a diluent, wherein the oral effervescent composition results in an unit dose of N-acetylcysteine selected from the group consisting of 0.5 g, 1.0 g, 1.5 g, 2.0 g and 2.5 g.

2. The oral effervescent composition according to claim 1 wherein the amount of N-acetylcysteine is from 50% to 80% w/w of the composition.

3. The oral effervescent composition according to claim 2 wherein the amount of N-acetylcysteine is from 50% to 60% w/w of the composition.

4. The oral effervescent composition according to claim 3 wherein the amount of N-acetylcysteine is from 54% to 55% w/w of the composition.

5. The oral effervescent composition according to claim 1, wherein the amount of the sweetener is from 0.2% to 10% w/w of the mixture of pharmaceutically acceptable excipients.

6. The oral effervescent composition according to claim 5, wherein the amount of the sweetener is from 0.5 to 1% w/w of the mixture of pharmaceutically acceptable excipients.

7. The oral effervescent composition according to claim 1, wherein the amount of the flavorant is from 1% to 3% w/w of the mixture of pharmaceutically acceptable excipients.

8. The oral effervescent composition according to claim 7, wherein the amount of the flavorant is about 2% w/w of the mixture of pharmaceutically acceptable excipients.

9. The oral effervescent composition according to claim 1, wherein the amount of the diluent is from 2% to 20% w/w of the mixture of pharmaceutically acceptable excipients.

10. The oral effervescent composition according to claim 1, wherein the carbonate or bicarbonate salt is selected from the group consisting of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, sodium sesquicarbonate, and sodium glycine carbonate.

11. The oral effervescent composition according to claim 1, wherein the amount of carbonate or bicarbonate salt is from 20% to 45% w/w of the composition.

12. The oral effervescent composition according to claim 11, wherein the amount of carbonate or bicarbonate salt is from 30% to 35% w/w of the composition.

13. The oral effervescent composition according to claim 1, wherein the sweetener is selected from the group consisting of sugars and artificial sweeteners.

14. The oral effervescent composition according to claim 13, wherein the artificial sweetener is selected from the group consisting of sodium saccharin, acesulfame potassium, cyclamates, and sucralose.

15. The oral effervescent composition according to claim 14, wherein the artificial sweetener is sucralose.

16. The oral effervescent composition according to claim 1, wherein the diluent is selected from the group consisting of polyols, cellulose, starch and maltodextrin.

17. The oral effervescent composition according to claim 16, wherein the diluent is maltodextrin.

18. The oral effervescent composition according to claim 1, further comprising a lubricant.

19. The oral effervescent composition according to claim 18, wherein the lubricant is sodium benzoate.

20. The oral effervescent composition according to claim 1 obtained by wet granulation in a fluid bed granulator.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Cipla
Chinese Patent Office
Merck
UBS
McKinsey
Novartis
Cerilliant
US Department of Justice
Farmers Insurance
Dow

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot