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Details for Patent: 9,402,851

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Details for Patent: 9,402,851

Title:Process for the preparation of a solid, orally administrable pharmaceutical composition
Abstract: A process for the preparation of a solid, orally administrable pharmaceutical composition, comprising 5-chloro-N-({(5)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-- 5-yl}-methyl)-2-thiophenecarboxamide comprising preparing granules in hydrophilized form using fluidized bed granulation for moist granulation, adding additives, compressing to form a tablet, and coating the tablet.
Inventor(s): Benke; Klaus (Bergisch Gladbach, DE)
Assignee: Bayer Intellectual Property GmbH (Monheim, DE)
Filing Date:Mar 10, 2014
Application Number:14/202,481
Claims:1. A process for the preparation of a solid, orally administrable pharmaceutical tablet comprising an active compound (I) that is 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin- -5-yl}-methyl)-2-thiophenecarboxamide in hydrophilized form, comprising the following steps: (a) preparing granules comprising the active compound (I) in hydrophilized form using fluidized bed granulation for moist granulation; (b) adding at least one pharmaceutically suitable additive to the granules and compressing to form a tablet; and (c) coating to form the pharmaceutical tablet.

2. The process according to claim 1, wherein the resulting pharmaceutical tablet rapidly releases the active compound (I).
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