Details for Patent: 9,365,587

Title:	Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
Abstract:	The invention is a process for the preparation of a compound of the following formula (I): ##STR00001## wherein R is --CHO, --CH(OH).sub.2 or --CH(OH)(OR.sup.4); P.sup.1 is H or a hydroxyl protecting group; P.sup.3 is H or a carboxy protecting group; R.sup.3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R.sup.x is H, halogen or R.sup.2--X--NR.sup.1--C(O)--; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.
Inventor(s):	Yoshida; Hiroshi (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP), Johns; Brian Alvin (Research Triangle Park, NC), Kawasuji; Takashi (Osaka, JP), Nagamatsu; Daiki (Osaka, JP)
Assignee:	SHIONOGI & CO., LTD. (Osaka, JP) ViiV HEALTHCARE COMPANY (Research Triangle Park, NC)
Filing Date:	Nov 10, 2015
Application Number:	14/936,987
Claims:	1. A process for the preparation of a compound of the following formula (I): ##STR00038## wherein R is --CHO, --CH(OH).sub.2 or --CH(OH)(OR.sup.4); P.sup.1 is H or a hydroxyl protecting group; P.sup.3 is H or a carboxy protecting group; R.sup.3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterocyclic group, optionally substituted heterocycleoxy and optionally substituted amino; R.sup.4 is lower alkyl; R.sup.x is H, halogen or R.sup.2--X--NR.sup.1--C(O)--; R.sup.2 is optionally substituted aryl; X is a single bond, a heteroatom group selected from the group consisting of O, S, SO, SO.sub.2, and NH or a lower alkylene or a lower alkenylene wherein each may be intervened by the heteroatom; and R.sup.1 is H or lower alkyl, which comprises the steps of: i) reacting a compound of formula (II): ##STR00039## wherein P.sup.1, P.sup.3, R.sup.x and R.sup.3 are defined above; with an amine of formula (III) or (IV): ##STR00040## wherein R.sup.5 and R.sup.6 are independently lower alkyl or R.sup.5 and R.sup.6 can be alkyl and joined to form a 5-, 6-, or 7-membered ring, to produce an intermediate of formula (V) or (VI), respectively: ##STR00041## wherein P.sup.1, P.sup.3, R.sup.x, R.sup.3, R.sup.5 and R.sup.6 are defined above; and ii) refunctionalizing the intermediate of formula (V) or (VI) to produce the compound of formula (I). 2. The process according to claim 1, wherein in the compound of formula (I), R.sup.x is H or Br. 3. The process according to claim 1, wherein in the compound of formula (I), P.sup.1 is H or Bn. 4. The process according to claim 1, wherein in the compound of formula (I), R.sup.3 is H. 5. The process according to claim 1, wherein in the compound of formula (I), P.sup.3 is H or Me. 6. The process according to claim 1, wherein the compound of formula (II) is ##STR00042## 7. The process according to claim 1, wherein the compound of formula (VI) is ##STR00043## 8. The process according to claim 1, wherein the compound of formula (VI) is ##STR00044## 9. The process according to claim 1, wherein the compound of formula (I) is ##STR00045## 10. The process according to claim 1, wherein the amine is H.sub.2NCH.sub.2CH.sub.2CH.sub.2OH. 11. The process according to claim 1, wherein R.sup.x is p-F-phenyl-CH.sub.2--NH--C(O)--, R.sup.3 is H, P.sup.1 is Bn and P.sup.3 is a carboxy protecting group. 12. The process according to claim 1, wherein step i) is carried out in EtOH, THF or DMF at a temperature of about 50-150.degree. C. 13. The process according to claim 1, wherein step ii) is carried out using the intermediate of formula (VI) with an oxidizing agent selected from the group consisting of NaIO.sub.4, RuO.sub.4 and Pb(OAc).sub.4 in a solvent selected from the group consisting of H.sub.2O, MeOH and CH.sub.3CN. 14. The process according to claim 1, wherein step ii) is carried out using the intermediate of formula (V) with an acid selected from the group consisting of HCl, CF.sub.3COOH and HCOH. 15. The process according to claim 1, wherein step ii) includes refunctionalization of R.sup.x from R.sup.x=H to R.sup.x=Br. 16. The process according to claim 1, wherein step ii) includes refunctionalization of R.sup.x to R.sup.x=R.sup.2--X--NR.sup.1--C(O)--. 17. The process according to claim 1, wherein step ii) includes refunctionalization of P.sup.3 from P.sup.3=H to P.sup.3=Me.