Generated: May 29, 2017
|Title:||Liquid pharmaceutical formulations of palonosetron|
|Abstract:||The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.|
|Inventor(s):||Calderari; Giorgio (Rancate, CH), Bonadeo; Daniele (Casalzuigno, IT), Cannella; Roberta (Varese, IT), Macciocchi; Alberto (Melide, CH), Miksztal; Andrew (Palo Alto, CA), Malefyt; Thomas (Carmel Valley, CA), Lee; Kathleen M (Palo Alto, CA), Panuccio; Carmine (Casnate con Bernate, IT)|
|Assignee:||HELSINN HEALTHCARE SA (CH) ROCHE PALO ALTO LLC (Palo Alto, CA)|
|Filing Date:||Nov 04, 2013|
|Claims:||1. A pharmaceutical single-use, unit-dose formulation for intravenous administration to a human to reduce the likelihood of cancer chemotherapy-induced nausea and vomiting, comprising a 50 mL sterile isotonic solution buffered at a pH of 4.8.+-.0.5 comprising: palonosetron hydrochloride in an amount of 0.75 mg based on the weight of its free base; 450.0 mg sodium chloride; 2.5 mg EDTA; 18.5 mg sodium citrate; and 7.8 mg citric acid monohydrate, wherein said formulation is contained in a polyethylene multilayer film infusion bag comprising an isoprene rubber stopper.|
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.