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Generated: September 25, 2017

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Title:Crystalline forms of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide
Abstract: The present invention relates to novel crystalline forms of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide. Processes for the preparation of this form, compositions containing the form, and methods of use thereof are also described.
Inventor(s): Surana; Rahul (Coram, NY), Dedhiya; Mahendra G. (Pomona, NY)
Assignee:
Filing Date:Oct 20, 2014
Application Number:14/518,300
Claims:1. A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 12.0, 20.1 and 22.5.+-.0.2 degrees 2.theta..

2. The crystalline form of claim 1, wherein the X-ray powder diffraction pattern further comprises a characteristic peak at 32.7.+-.0.2 degrees 2.theta..

3. The crystalline form of claim 1, wherein the X-ray powder diffraction pattern further comprises a characteristic peak at 6.0.+-.0.2 degrees 2.theta..

4. A pharmaceutical composition comprising the crystalline form of claim 1 and a pharmaceutically acceptable carrier.

5. A method of treating a disorder that can be managed by inhibition of norepinephrine and serotonin reuptake in a patient in need thereof, by administering to said patient an effective amount of a pharmaceutical compositions that comprises the crystalline form of claim 1.

6. A process for preparing the crystalline form of claim 1, comprising dissolving (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide and precipitating the crystalline form.
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Serving 500+ biopharmaceutical companies globally:

Fuji
Chubb
Teva
Citi
Healthtrust
Harvard Business School
US Army
Mallinckrodt
Federal Trade Commission
Dow

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