Details for Patent: 9,241,915
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Title: | Method for enhancing the bioavailability of ospemifene |
Abstract: | This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00001## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food. |
Inventor(s): | Anttila; Markku (Turku, FI) |
Assignee: | QuatRx Pharmaceuticals (Ann Arbor, MI) |
Filing Date: | Jun 20, 2014 |
Application Number: | 14/310,822 |
Claims: | 1. A method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00005## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to an individual in connection with the intake of food. 2. The method according to claim 1 wherein compound (I) is ospemifene. 3. The method according to claim 1 wherein the compound is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake. 4. The method according to claim 3 wherein the compound is administered at a time point which is in the range defined to begin at a time point during the food intake and to end 1 hour after the food intake was started. 5. The method according to claim 4 wherein the compound is administered at a time point which is no later than 0.5 hour after starting the food intake. 6. The method according to claim 1 wherein the food is any foodstuff of nutritional value being capable of causing secretion of bile acids. 7. The method according to claim 1 wherein the compound is used for treatment of osteoporosis. 8. The method according to claim 1 wherein the compound is used for treatment of symptoms related to skin atrophy, or to epithelial or mucosal atrophy. 9. The method according to claim 8 wherein the symptoms are urinary symptoms or vaginal symptoms. |