.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 9,186,364

« Back to Dashboard

Details for Patent: 9,186,364

Title:Formulations of deoxycholic acid and salts thereof
Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.
Inventor(s): Hodge; Robert Emil (McPherson, KS), Webster; Jeffrey Douglas (Thousand Oaks, CA)
Assignee: KYTHERA BIOPHARMACEUTICALS, INC. (Westlake Village, CA)
Filing Date:Jan 03, 2013
Application Number:13/733,729
Claims:1. A method for substantially inhibiting precipitation of sodium deoxycholate in an aqueous solution consisting of less than 5% w/v of sodium deoxycholate and optionally at least one of pharmaceutically acceptable excipient and/or carrier, said method comprising maintaining pH of the solution from about 8.0 to about 8.5 thereby substantially inhibiting precipitation of the sodium deoxycholate.

2. The method of claim 1, wherein the precipitation of sodium deoxycholate is substantially inhibited for a period of at least six months.

3. The method of claim 1, wherein one of the at least one of pharmaceutically acceptable excipient and/or carrier is about 1% benzyl alcohol.

4. The method of claim 1, wherein one of the at least one of pharmaceutically acceptable excipient and/or carrier is about 1% sodium chloride.

5. The method of claim 1, wherein the aqueous solution has a pH of about 8.3.

6. The method of claim 5, wherein the aqueous solution has a pH of 8.3.

7. The method of claim 1, wherein the sodium deoxycholate in solution has a relative standard deviation for homogeneity of less than about 5%.

8. The method of claim 1, wherein the aqueous solution comprises a sodium deoxycholate concentration from about 0.05% w/v to about 5% w/v.

9. A method for substantially inhibiting precipitation of sodium deoxycholate in an aqueous solution consisting of about 0.5% to about 1.5% w/v of sodium deoxycholate and optionally at least one of pharmaceutically acceptable excipient and/or carrier, said method comprising maintaining pH of the solution from about 8.0 to about 8.5 thereby substantially inhibiting precipitation of the sodium deoxycholate.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc