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Details for Patent: 9,180,259

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Details for Patent: 9,180,259

Title:Prefilled syringe jet injector
Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.
Inventor(s): Lesch, Jr.; Paul R. (Lino Lakes, MN)
Assignee: ANTARES PHARMA, INC. (Ewing, NJ)
Filing Date:Feb 05, 2014
Application Number:14/173,659
Claims:1. A jet injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament, an injection-assisting needle disposed at a distal end of the fluid chamber, the injection-assisting needle having an injection tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the fluid chamber for injecting the medicament from the fluid chamber into an injection site, wherein the injection-assisting needle is adhered to the container portion, a syringe body that includes a flange and a wall and hub of unitary construction, and a plunger movable within the fluid chamber; a housing that houses the prefilled syringe and is configured for allowing insertion of the injection-assisting needle at the injection location to an insertion point that is at a penetration depth below a surface at the insertion location, wherein the housing comprises a retractable guard that is movable between: a protecting position in which the injection-assisting needle is disposed within the guard; and an injecting position in which the tip of the injection-assisting needle is exposed for insertion to the insertion point; a syringe support supportively mounting the prefilled syringe to the housing; a syringe cushion associated with the syringe support and prefilled syringe and made of an elastomeric material to compensate for shape irregularities of the pre-filled syringe; an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains below 500 p.s.i. during the injection of the medicament to jet inject the medicament from the fluid chamber through the injection-assisting needle to the injection site; and a trigger mechanism operably associated with the energy source for activating the energy source to jet inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the retractable guard is retracted from the protecting position, wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament.

2. The jet injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains up to about 350 p.s.i. during the injection of the medicament.

3. The jet injector of claim 2, wherein the energy source is configured to produce the injecting pressure that remains at least at about 90 p.s.i. during the injection of the medicament.

4. The jet injector of claim 1, wherein the penetration depth is between about 0.5 mm and 5 mm below the surface at the insertion location.

5. The jet injector of claim 1, wherein the housing is configured for allowing insertion of the needle to subcutaneous depth.

6. The jet injector of claim 1, wherein the energy source comprises a spring.

7. The jet injector of claim 6, further comprising a ram that is biased by the spring against the plunger to produce the injection pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the jet injector is fired, such that the spring surrounds the prefilled syringe.

8. The jet injector of claim 1, wherein: the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion; and the syringe support axially supports the proximal portion of the pre-filled syringe during the jet injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axially direction.

9. The jet injector of claim 1, wherein the fluid chamber contains about between 0.02 mL and 4 mL of the medicament.

10. The jet injector of claim 1, wherein the retractable guard is operably associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the retractable guard is retracted to the injecting position.

11. The jet injector of claim 1, wherein the prefilled syringe is associated with the housing in a fixed position before and during activation of the energy source for firing of the jet injector.

12. The jet injector of claim 1, wherein the syringe cushion comprises a resilient sleeve portion configured to provide shock absorption during firing of the jet injector.

13. The jet injector of claim 1, wherein the syringe cushion supports the flange.
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