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Details for Patent: 9,163,057

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Details for Patent: 9,163,057

Title:Methods of myocardial perfusion imaging
Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopu- rin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
Inventor(s): Belardinelli; Luiz (Palo Alto, CA), Blackburn; Brent K. (Los Altos, CA), Gao; Zhenhai (San Jose, CA)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Filing Date:Aug 29, 2013
Application Number:14/014,169
Claims:1. A method for increasing coronary blood flow in a mammal in need thereof comprising administering a pharmaceutically effective amount of a compound that is ##STR00004## wherein the pharmaceutically effective amount is about 0.3 to 103 .mu.g/kg, and wherein the administration causes an increase in peripheral blood flow that is less than 50% of the increase in coronary blood flow.

2. The method of claim 1, wherein the dose of the compound is 30 .mu.g/kg.

3. The method of claim 1, wherein the step of administering the pharmaceutically effective amount of the compound takes place by infusion of a pharmaceutically acceptable composition thereof.

4. The method of claim 1, wherein the step of administering the pharmaceutically effective amount of the compound takes place by a bolus injection of a pharmaceutically acceptable composition thereof.

5. A method of myocardial perfusion imaging in a human in need thereof comprising: administering to the human (a) a dose of a compound ##STR00005## wherein the dose is about 0.3 to 103 .mu.g/kg and (b) a radionuclide, and thereafter determining areas of insufficient blood flow.
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