Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Preparation of bile acids and intermediates thereof|
|Abstract:||Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.|
|Inventor(s):||Prasad; Achampeta Rathan (Hyderabad, IN), Swaringen, Jr.; Roy A. (Durham, NC), Reid; John Gregory (Groton, MA), Moriarty; Robert M. (Michiana Shores, IN), Sahoo; Akhila Kumar (Hyderabad, IN)|
|Assignee:||KYTHERA BIOPHARMACEUTICALS, INC. (Westlake Village, CA)|
|Filing Date:||Dec 28, 2012|
|Claims:||1. A method of preparing a compound of formula 1.7: ##STR00029## comprising reacting a compound of formula 1.6: ##STR00030## with an alkylpropiolate HC.ident.CC(O)OR or an alkyl acrylate CH.sub.2.dbd.CHC(O)OR wherein R is alkyl in the presence of a Lewis acid to form a compound of formula 1.7 wherein P is a protecting group, R is a alkyl, and the dashed line ---- is a single or double bond, to provide the compound of formula 1.7. |
2. The method of claim 1 wherein the Lewis acid is EtCl.sub.2.
3. The method of claim 1 wherein the alkylpropiolate or alkylacrylate is methylpropriolate or methylacrylate.
4. A method of preparing a compound of formula 2.1: ##STR00031## comprising reacting a compound of formula 2.0 ##STR00032## with a reducing agent to form a compound of formula 2.1 wherein P is a protecting group and R is alkyl, to provide a compound of formula 2.1.
5. The method of claim 4 wherein the reducing agent is LiAl(OtBu).sub.3H.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.