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Chinese Patent Office
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Daiichi Sankyo

Generated: May 22, 2018

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Details for Patent: 9,090,575

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Title:Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Abstract: The invention provides compounds represented by the general formula I ##STR00001## wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
Inventor(s): Ruhland; Thomas (Roskilde, DK), Smith; Garrick P. (Valby, DK), Bang-Andersen; Benny (Copenhagen S, DK), Puschl; Ask (Frederiksberg, DK), Moltzen; Ejner K. (Gentofte, DK), Andersen; Kim (Ridgewood, NJ)
Assignee: H. Lundbeck A/S (Copenhagen-Valby, DK)
Filing Date:Jun 26, 2013
Application Number:13/927,678
Claims:1. A process for the manufacture of a compound represented by formula Ia: ##STR00015## wherein s is 2; each R.sup.3 is independently selected from a group represented by halogen, cyano, nitro, C.sub.1-6-alkyl, or C.sub.1-6-alkyloxy; or an acid addition salt thereof, the process comprising reacting a compound of formula IVa ##STR00016## with a compound of the formula Cl--CH.sub.2--CH.sub.2--NH--CH.sub.2--CH.sub.2--Cl or Br--CH.sub.2--CH.sub.2--NH--CH.sub.2--CH.sub.2--Br.

2. The process of claim 1, wherein each R.sup.3 is independently C.sub.1-6-alkyl.

3. The process of claim 1, wherein the compound of formula Ia is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine.

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