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Details for Patent: 9,072,857

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Details for Patent: 9,072,857

Title:Nasal delivery device
Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.
Inventor(s): Djupesland; Per Gisle (Oslo, NO)
Assignee: OptiNose AS (Oslo, NO)
Filing Date:Jun 02, 2006
Application Number:11/446,424
Claims:1. A device for delivering a substance to the nasal airway of a subject, comprising: a delivery unit for delivering a substance to one of the nostrils of the subject, wherein the delivery unit comprises a nosepiece including an outlet through which the substance is in use delivered to the one nostril and a sealing member configured to seal the one nostril of the subject to the outlet, the sealing member having a first, distal end and a second, proximal end and being enlarged towards the proximal end to cause an anterior region of the nasal cavity into which the nosepiece is inserted to be enlarged, a liquid aerosol spray generator actuatable during exhalation by the subject to generate a liquid aerosol spray containing a metered dose of the substance through the outlet to the nasal airway, and a flow resistor, wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject.

2. The device of claim 1, wherein the flow resistor is operably connected to a tubular section configured to be held between the lips of the subject.

3. The device of claim 1, wherein the flow resistor is operably connected to a mouthpiece.

4. The device of claim 1, wherein the flow resistor is fluidly connected to the nosepiece.

5. The device of claim 1, wherein the delivery unit is configured to deliver the gas flow at a driving pressure which, with closure of the oropharyngeal velum of the subject, would be such as to cause the gas to flow around the posterior margin of the nasal septum and out of the other nostril of the subject.

6. The device of claim 1, further comprising: an outlet unit comprising a nosepiece for fitting to the other nostril and a flow resistor for providing a flow resistance to the gas flow exiting the other nostril, so as in use to maintain a positive dynamic pressure upstream thereof.

7. The device of claim 6, wherein the flow resistor of the outlet unit is adjustable to allow for adjustment of the flow resistance.

8. The combination of the device of claim 1 and a substance to be delivered.

9. The combination of claim 8, wherein the substance comprises a steroid.

10. The combination of claim 8, wherein the substance comprises oxytocin.

11. The combination of claim 8, wherein the substance comprises an anti-migraine pharmaceutical.

12. The combination of claim 8, wherein the substance comprises an anti-allergic pharmaceutical.

13. The combination of claim 8, wherein the substance comprises an anti-inflammatory pharmaceutical.

14. A device for delivering a substance to the nasal airway of a subject, comprising: a delivery unit for delivering a substance to one of the nostrils of the subject, wherein the delivery unit comprises a nosepiece including an outlet through Which the substance is in use delivered to the one nostril and a sealing member configured to seal the one nostril of the subject to the outlet, the sealing member having a first, distal end and second, proximal end and being enlarged towards the proximal end to cause an anterior region of the nasal cavity into which the nosepiece is inserted to be enlarged: a liquid aerosol spray generator actuatable during exhalation by the subject to generate an liquid aerosol spray containing a metered dose of the substance through the outlet to the nasal airway: a flow resistor, wherein the device is configured create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject; and an indicator for providing at least one of a visual or an audible signal on exhalation by the subject against the flow resistor.
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