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Generated: February 23, 2018

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Title:Compositions and methods for treatment
Abstract: The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
Inventor(s): Zhong; Min (Foster City, CA), Shen; Wang (San Mateo, CA), Oslob; Johan D. (Sunnyvale, CA), Barr; Kenneth (Boston, MA)
Assignee: SARcode Bioscience Inc. (Bisbane, CA)
Filing Date:May 12, 2014
Application Number:14/275,159
Claims:1. A compound having the following formula: ##STR00042## or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable vehicle.

3. The pharmaceutical composition of claim 2 wherein the pharmaceutically acceptable vehicle is suitable for ocular administration.

4. The pharmaceutical composition of claim 3 further comprising a preservative.
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Serving leading biopharmaceutical companies globally:

US Department of Justice
Healthtrust
UBS
Daiichi Sankyo
Harvard Business School
Mallinckrodt
Chinese Patent Office
Boehringer Ingelheim
Fish and Richardson
Baxter

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