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Details for Patent: 8,916,191

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Details for Patent: 8,916,191

Title:Device for transdermal administration of drugs including acrylic polymers
Abstract: A transdermal delivery system is provided where the drug delivery rates, onset and profiles of at least one active agent are controlled by selectively manipulating the monomeric make up of an acrylic-based polymer in the transdermal drug delivery system. The drug carrier composition may be comprised of (a) one or more acrylic-based polymers having one or more different monomers selected from the group consisting of hard and soft monomers; (b) one or more silicone-based polymers; and (c) one or more active agents where the device provides a desired solubility for the active agent and controls drug delivery rates, onset and profiles of at least one active agent.
Inventor(s): Kanios; David (Palmetto Bay, FL)
Assignee: Noven Pharmaceuticals, Inc. (Miami, FL)
Filing Date:Apr 04, 2014
Application Number:14/245,398
Claims:1. A transdermal drug delivery system comprising a carrier composition comprising a blend of: (a) a polymer composition comprising at least one acrylic-based polymer polymerized from monomers that consist of: (i) soft acrylic monomers selected from the group consisting of 2-ethyl hexyl acrylate, isobutyl acrylate, ethyl acrylate, butyl acrylate, dodecyl methacrylate, 2-ethylhexyl methacrylate, 2-ethoxyethyl acrylate, isopropyl acrylate, and 2-methoxyethyl acrylate, in an amount of 20% by weight of the acrylic-based polymer; and (ii) hard acrylic monomers selected from the group consisting of methacrylate, N-butyl acrylate, acrylic acid, butyl methacrylate, ethyl methacrylate, methyl methacrylate, hexyl methacrylate, and methyl acrylate, in an amount of 80% by weight of the acrylic-based polymer; and (b) a drug in an amount of from 0.1% to 50% by weight of the carrier composition, wherein all acrylic-based polymers present in said polymer composition of the transdermal drug delivery system are polymerized from monomers that consist of monomers selected from the group consisting of said soft and hard acrylic monomers (i) and (ii).

2. The transdermal drug delivery system according to claim 1, wherein the drug is methylphenidate.

3. The transdermal drug delivery system according to claim 1, wherein the drug is amphetamine.

4. The transdermal drug delivery system according to claim 1, wherein the drug is present in an amount from 0.3% to 30% by weight of the carrier composition.

5. The transdermal drug delivery system according to claim 1, wherein the drug is present in an amount from 0.5% to 15% by weight.

6. The transdermal drug delivery system according to claim 1, wherein the drug is present in said transdermal drug delivery system from about 1% to about 10% by weight.

7. The transdermal drug delivery system according to claim 1, wherein the soft acrylic monomer comprises 2-ethyl hexyl acrylate.

8. The transdermal drug delivery system according to claim 1, wherein the hard acrylic monomer comprises methacrylate.

9. The transdermal drug delivery system according to claim 1, wherein the acrylic-based polymer is present in an amount of from 2 to 95% by weight of the carrier composition, based on the dry weight of the carrier composition.

10. The transdermal drug delivery system according to claim 1, wherein the acrylic-based polymer is present in an amount of from 2 to 90% by weight of the carrier composition, based on the dry weight of the carrier composition.

11. The transdermal drug delivery system according to claim 1, wherein the acrylic-based polymer is present in an amount of from 2 to 85% by weight of the carrier composition, based on the dry weight of the carrier composition.

12. The transdermal drug delivery system according to claim 1, wherein all acrylic-based polymers present in said polymer composition are acrylic-based polymers polymerized from monomers that include (i) soft acrylic monomers selected from the group consisting of 2-ethyl hexyl acrylate, isobutyl acrylate, ethyl acrylate, butyl acrylate, dodecyl methacrylate, 2-ethylhexyl methacrylate, 2-ethoxyethyl acrylate, isopropyl acrylate, and 2-methoxyethyl acrylate, in an amount of 20% by weight of the acrylic-based polymer; and (ii) hard acrylic monomers selected from the group consisting of methacrylate, N-butyl acrylate, acrylic acid, butyl methacrylate, ethyl methacrylate, methyl methacrylate, hexyl methacrylate, and methyl acrylate, in an amount of 80% by weight of the acrylic-based polymer.

13. The transdermal drug delivery system according to claim 1, further comprising a backing layer.

14. The transdermal drug delivery system according to claim 1, further comprising a release liner.

15. A method for transdermally delivering a drug to a subject in need thereof comprising administering the transdermal drug delivery system according to claim 1 to said subject.
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