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Generated: December 16, 2017

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Title:Methods of making compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity
Abstract: A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulstion for internal, oral, direct or topical administration.
Inventor(s): Lichtenberger; Lenard M. (Houston, TX)
Assignee: The Board of Regents of the University of Texas System (Austin, TX)
Filing Date:Sep 16, 2010
Application Number:12/883,918
Claims:1. A method for producing a pharmaceutical composition that is a NSAID-in-oil suspension, said method comprising admixing a NSAID in powder form into a lecithin oil to obtain a NSAID-in-oil suspension, such that the NSAID (i) associates with phospholipids in the lecithin oil and (ii) is present in a therapeutically effective amount and the NSAID-in-oil suspension has a gastrointestinal toxicity that is reduced relative to the NSAID alone, wherein said NSAID is selected from the group consisting of aspirin, indomethacin and ibuprofen.

2. The method of claim 1, wherein the NSAID is aspirin.

3. The method of claim 1, wherein the weight ratio of NSAID to lecithin oil present in the NSAID-in-oil suspension is from about 4:1 to about 1:4.

4. The method of claim 3, wherein the weight ratio of NSAID to lecithin oil is about 1:1.

5. The method of claim 1, wherein said lecithin oil comprises about 35% phosphatidylcholine.

6. The method of claim 2, wherein said lecithin oil comprises about 35% phosphatidylcholine.
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