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|Title:||Myocardial perfusion imaging methods and compositions|
|Abstract:||A myocardial imaging method that is accomplished by administering one or more adenosine A.sub.2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A.sub.2a receptor agonist, at least one liquid carrier, and at least one co-solvent.|
|Inventor(s):||Belardinelli; Luiz (Palo Alto, CA), Rosner; Mitchell (Mountain View, CA)|
|Assignee:||Gilead Sciences, Inc. (Foster City, CA)|
|Filing Date:||Mar 21, 2013|
|Claims:||1. A method for myocardial perfusion imaging comprising administering to a human subject in need thereof a compound which has the formula: ##STR00020## with saline and followed by a radionuclide, wherein the myocardium is examined for areas of insufficient blood flow following the administration of the radionuclide. |
2. The method of claim 1, wherein the method comprises administering the compound by intravenous (iv) bolus.
3. A method for myocardial perfusion imaging comprising administering a single bolus intravenous injection of a pharmaceutical composition comprising a compound which has the formula: ##STR00021## to a human subject in need thereof, wherein the compound is administered in an amount of 10 .mu.g to about 1000 .mu.g, and the amount is independent of the human subject's weight.