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Last Updated: March 29, 2024

Details for Patent: 8,871,935


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Title:Crystalline pharmaceutical and methods of preparation and use thereof
Abstract: Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. ##STR00001##
Inventor(s): Burnier; John (Pacifica, CA), Gadek; Thomas (Oakland, CA), Naud; Frederic (Binningen, CH)
Assignee: SARcode Bioscience Inc. (Brisbane, CA)
Filing Date:Dec 11, 2012
Application Number:13/710,651
Claims:1. A method of synthesizing a compound of Formula I: ##STR00028## comprising the steps: a) hydrogenolyzing an ester of Formula A with a palladium catalyst and a source of protons; and ##STR00029## b) isolating a compound of Formula I.

2. The method of claim 1, wherein the palladium catalyst is 10% palladium on carbon.

3. The method of claim 1, wherein the proton source is formic acid.

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