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|Title:||Crystalline pharmaceutical and methods of preparation and use thereof|
|Abstract:||Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. ##STR00001##|
|Inventor(s):||Burnier; John (Pacifica, CA), Gadek; Thomas (Oakland, CA), Naud; Frederic (Binningen, CH)|
|Assignee:||SARcode Bioscience Inc. (Brisbane, CA)|
|Filing Date:||Dec 11, 2012|
|Claims:||1. A method of synthesizing a compound of Formula I: ##STR00028## comprising the steps: a) hydrogenolyzing an ester of Formula A with a palladium catalyst and a source of protons; and ##STR00029## b) isolating a compound of Formula I. |
2. The method of claim 1, wherein the palladium catalyst is 10% palladium on carbon.
3. The method of claim 1, wherein the proton source is formic acid.