Details for Patent: 8,841,330
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Title: | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
Abstract: | This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. |
Inventor(s): | Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Orange, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy B. (Nishinomiya, JP), Scott; William J. (Guilford, CT), Smith; Roger A. (Madison, CT), Wood; Jill E. (North Haven, CT) |
Assignee: | Bayer Healthcare LLC (Whippany, NJ) |
Filing Date: | Feb 08, 2012 |
Application Number: | 13/368,812 |
Claims: | 1. A method for the treatment of a tumor of the prostate, breast, liver, ovary or cervix in a human or animal comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00186## or a pharmaceutically acceptable salt thereof. 2. A method as in claim 1 wherein the tumor is of the prostate. 3. A method of claim 1 wherein the tumor is of the breast. 4. A method of claim 1 wherein the tumor is of the liver. 5. A method of claim 1 wherein the tumor is of the ovary. 6. A method of claim 1 wherein the tumor is of the cervix. 7. A method for the treatment of a tumor of the prostate, breast, liver, ovary or cervix in a human or animal comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00187## 8. A method as in claim 7 wherein the tumor is of the prostate. 9. A method of claim 7 wherein the tumor is of the breast. 10. A method of claim 7 wherein the tumor is of the liver. 11. A method of claim 7 wherein the tumor is of the ovary. 12. A method of claim 7 wherein the tumor is of the cervix. 13. A method for the treatment of liver cancer in a human or animal in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00188## or a pharmaceutically acceptable salt thereof. 14. A method of claim 13 wherein a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00189## is administered. |