Details for Patent: 8,778,962
✉ Email this page to a colleague
Title: | Treatment of solid tumors with rapamycin derivatives |
Abstract: | Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent. |
Inventor(s): | Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH) |
Assignee: | Novartis Pharmaceuticals Corporation (East Hanover, NJ) |
Filing Date: | Jul 11, 2012 |
Application Number: | 13/546,686 |
Claims: | 1. A method for inhibiting growth of non-malignant solid tumors of the brain in a subject, said method consisting of administering to said subject a therapeutically effective amount of a compound of formula I ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O. 2. The method of claim 1 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses. 3. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg. 4. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg. 5. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of 10 mg. 6. The method of claim 1 wherein the compound of formula I is administered orally. |