Details for Patent: 8,772,482
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Title: | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
Abstract: | Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ##STR00001## |
Inventor(s): | Devasagayaraj; Arokiasamy (Plainsboro, NJ), Jin; Haihong (Manalapan, NJ), Shi; Zhi-Cai (Monmouth Junction, NJ), Tunoori; Ashok (Princeton, NJ), Wang; Ying (Plainsboro, NJ), Zhang; Chengmin (Morristown, NJ) |
Assignee: | Lexicon Pharmaceuticals, Inc. (The Woodlands, TX) |
Filing Date: | Jun 17, 2011 |
Application Number: | 13/162,989 |
Claims: | 1. A method of treating or managing irritable bowel syndrome, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR00055## or a pharmaceutically acceptable salt thereof, wherein R.sub.4 is lower alkyl. 2. A method of treating or managing Crohn's disease, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR00056## or a pharmaceutically acceptable salt thereof, wherein R.sub.4 is hydrogen or lower alkyl. 3. The method of claim 2, wherein R.sub.4 is hydrogen. 4. The method of claim 2, wherein R.sub.4 is lower alkyl. 5. The method of claim 4, wherein R.sub.4 is ethyl. 6. A method of treating or managing ulcerative colitis, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR00057## or a pharmaceutically acceptable salt thereof, wherein R.sub.4 is hydrogen or lower alkyl 7. The method of claim 6, wherein R.sub.4 is hydrogen. 8. The method of claim 6, wherein R.sub.4 is lower alkyl. 9. The method of claim 8, wherein R.sub.4 is ethyl. |