Generated: May 23, 2017
|Title:||Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates|
|Abstract:||A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: ##STR00001## whereby a final product such as AA: ##STR00002## can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.|
|Inventor(s):||Yoshida; Hiroshi (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP), Johns; Brian Alvin (Research Triangle Park, NC), Kawasuji; Takashi (Osaka, JP), Nagamatsu; Daiki (Osaka, JP)|
|Assignee:||Shionogi & Co., Ltd. (Osaka, JP) ViiV Healthcare Company (Research Triangle Park, NC)|
|Filing Date:||Dec 04, 2013|
|Claims:||1. A compound of the following formula (DD): ##STR00047## wherein P.sup.1 is H or a carboxy protecting group. |
2. The compound of claim 1, wherein P.sup.1 is benzyl.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.