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Generated: January 24, 2018

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Title:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
Abstract: A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: ##STR00001## whereby a final product such as AA: ##STR00002## can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
Inventor(s): Yoshida; Hiroshi (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP), Johns; Brian Alvin (Research Triangle Park, NC), Kawasuji; Takashi (Osaka, JP), Nagamatsu; Daiki (Osaka, JP)
Assignee: Shionogi & Co., Ltd. (Osaka, JP) ViiV Healthcare Company (Research Triangle Park, NC)
Filing Date:Dec 04, 2013
Application Number:14/096,191
Claims:1. A compound of the following formula (DD): ##STR00047## wherein P.sup.1 is H or a carboxy protecting group.

2. The compound of claim 1, wherein P.sup.1 is benzyl.
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