|Title:||Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates|
|Abstract:|| A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: ##STR00001## whereby a final product such as AA: ##STR00002## can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.|
|Inventor(s):|| Yoshida; Hiroshi (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP), Johns; Brian Alvin (Research Triangle Park, NC), Kawasuji; Takashi (Osaka, JP), Nagamatsu; Daiki (Osaka, JP) |
|Assignee:|| Shionogi & Co., Ltd. (Osaka, JP) ViiV Healthcare Company (Research Triangle Park, NC) |
|Filing Date:||Dec 04, 2013|
|Claims:||1. A compound of the following formula (DD): ##STR00047## wherein P.sup.1 is H or a carboxy protecting group. |
2. The compound of claim 1, wherein P.sup.1 is benzyl.