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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Argus Health
Daiichi Sankyo
Cantor Fitzgerald

Generated: May 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,741,925

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Title:Modulators of ATP-binding cassette transporters
Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Inventor(s): Hadida-Ruah; Sara (La Jolla, CA), Hazlewood; Anna (San Diego, CA), Grootenhuis; Peter (San Diego, CA), Van Goor; Fredrick (San Diego, CA), Singh; Ashvani (San Diego, CA), Zhou; Jinglan (San Diego, CA), McCartney; Jason (Cardiff by the Sea, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Filing Date:Oct 25, 2013
Application Number:14/063,785
Claims:1. A method of enhancing mucociliary clearance in a patient in need thereof, comprising the step of administering to the patient a pharmaceutical composition comprising N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide.

2. The method of claim 1, wherein the patient has wild-type CFTR.

3. The method of claim 1, wherein the patient suffers from chronic obstructive pulmonary disease (COPD).

4. The method of claim 1, wherein anion secretion across the CFTR is increased.

5. The method of claim 4, wherein the anion secretion is mediated by a chloride channel or a bicarbonate channel.

6. The method of claim 1, wherein fluid transport into the airway surface liquid of the patient is increased.

7. The method of claim 1, wherein periciliary fluid viscosity of the patient is improved.

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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Johnson and Johnson
Chinese Patent Office
Express Scripts

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