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Generated: November 17, 2017

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Title:Method of treating neurodegenerative diseases
Abstract: The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) ##STR00001## wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
Inventor(s): Jordan; Shaun (Germantown, MD), Kikuchi; Tetsuro (Tokushima, JP), Tottori; Katsura (Kamiita-cho, JP), Hirose; Tsuyoshi (Tokushima, JP), Uwahodo; Yasufumi (Tokushima, JP)
Assignee: Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP)
Filing Date:Dec 15, 2011
Application Number:13/327,618
Claims:1. A method of treating a patient suffering from at least one neurodegenerative disease selected from Alzheimer's disease and Parkinson's disease, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt or solvate thereof selected from hemihydrates, hydrates, and alcoholates, wherein said patient is a mammal: ##STR00003## wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.

2. The method according to claim 1, wherein the neurodegenerative disease is Alzheimer's disease.

3. The method according to claim 1, wherein the neurodegenerative disease is Parkinson's disease.

4. A method of treating a patient suffering from at least one neurodegenerative disease selected from Alzheimer's disease and Parkinson's disease, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound, or a pharmaceutically acceptable salt or solvate thereof selected from hemihydrates, hydrates, and alcoholates, wherein said patient is a mammal, and wherein the carbostyril compound 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydrocarbostyril- .

5. The method according to claim 4, wherein the neurodegenerative disease is Alzheimer's disease.

6. The method according to claim 4, wherein the neurodegenerative disease is Parkinson's disease.
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