.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 8,697,132

« Back to Dashboard

Details for Patent: 8,697,132

Title:Capsule and powder formulations containing lanthanum compounds
Abstract: The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The present invention also includes an oral pharmaceutical powder comprising lanthanum carbonate or lanthanum carbonate hydrate and a pharmaceutically acceptable excipient. The oral pharmaceutical capsules and powders of the present invention can be administered to treat a patient at risk of or suffering from hyperphosphatemia, at risk of or suffering from chronic kidney disease (CKD), at risk of or suffering from soft tissue calcification associated with CKD, or at risk of or suffering from secondary hyperparathyroidism.
Inventor(s): Withington; Roger (Farnharn, GB), Pierce; David (Hertfordshire, GB)
Assignee: Shire LLC (Florence, KY)
Filing Date:Nov 30, 2011
Application Number:13/307,718
Claims:1. An oral pharmaceutical powder comprising (1) lanthanum carbonate or lanthanum carbonate hydrate, (2) crospovidone, and (3) talc, wherein a plasma lanthanum concentration of a patient after administration of the powder is similar to a plasma lanthanum concentration of the patient after administration of a chewable tablet comprising lanthanum carbonate, dextrates, colloidal silicon dioxide, and magnesium stearate.

2. The powder of claim 1, wherein the lanthanum carbonate or lanthanum carbonate hydrate has the formula: La.sub.2(CO.sub.3).sub.3.nH.sub.2O wherein n has a value from 0 to 10.

3. The powder of claim 2, wherein n has a value from 3 to 6.

4. The powder of claim 1, wherein the lanthanum carbonate or lanthanum carbonate hydrate is in an amount from about 50% to about 95% by weight of the powder.

5. The powder of claim 1, wherein the crospovidone is in an amount from about 1.0% to about 15% by weight of the powder.

6. The powder of claim 1, wherein the talc is in an amount from about 0.01% to about 0.05% by weight of the powder.

7. The powder of claim 1, further comprising a diluent.

8. The powder of claim 7, wherein the diluent is dextrates.

9. The powder of claim 7, wherein the diluent is in an amount from about 5% to about 50% by weight of the powder.

10. The powder of claim 1, further comprising a flow aid.

11. The powder of claim 10, wherein the flow aid is colloidal silicon dioxide.

12. The powder of claim 10, wherein the flow aid is in an amount from about 0.1% to about 4.0% by weight of the powder.

13. The powder of claim 1 comprising (1) 86.7 wt % lanthanum carbonate hydrate, (2) 8.2 wt % dextrates, (3) 1.0 wt % colloidal silicon dioxide, (4) 4.0 wt % crospovidone, and (5) 0.025 wt % talc.

14. A method of treating hyperphosphatemia in a patient comprising administering to the patient an oral pharmaceutical powder comprising (1) lanthanum carbonate or lanthanum carbonate hydrate, (2) crospovidone, and (3) talc, wherein a plasma lanthanum concentration of the patient after administration of the powder is similar to a plasma lanthanum concentration of the patient after administration of a chewable tablet comprising lanthanum carbonate, dextrates, colloidal silicon dioxide, and magnesium stearate.

15. A method of treating a patient (1) at risk of or suffering from chronic kidney disease (CKD), (2) at risk of or suffering from soft tissue calcification associated with chronic kidney disease (CKD), or (3) at risk of or suffering from secondary hyperparathyroidism comprising administering to the patient an oral pharmaceutical powder comprising (1) lanthanum carbonate or lanthanum carbonate hydrate, (2) crospovidone, and (3) talc, wherein a plasma lanthanum concentration of the patient after administration of the powder is similar to a plasma lanthanum concentration of the patient after administration of a chewable tablet comprising lanthanum carbonate, dextrates, colloidal silicon dioxide, and magnesium stearate.

16. The method of claim 14, wherein the crospovidone is in an amount from about 1.0% to about 15% by weight of the powder.

17. The method of claim 14, wherein the talc is in an amount from about 0.01% to about 0.05% by weight of the powder.

18. The method of claim 14, wherein the powder further comprises a diluent.

19. The method of claim 14, wherein the powder further comprises a flow aid.

20. The method of claim 14, wherein the powder comprises (1) 86.7 wt % lanthanum carbonate hydrate, (2) 8.2 wt % dextrates, (3) 1.0 wt % colloidal silicon dioxide, (4) 4.0 wt % crospovidone, and (5) 0.025 wt % talc.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc