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Last Updated: March 28, 2024

Details for Patent: 8,680,105


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Title:Method of treating down's syndrome
Abstract: The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): ##STR00001## wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
Inventor(s): Jordan; Shaun (Germantown, MD), Kikuchi; Tetsuro (Tokushima, JP), Tottori; Katsura (Kamiita-cho, JP), Hirose; Tsuyoshi (Tokushima, JP), Uwahodo; Yasufumi (Tokushima, JP)
Assignee: Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP)
Filing Date:Dec 15, 2011
Application Number:13/327,607
Claims:1. A method of treating a disorder of the central nervous system associated with the 5-HT.sub.1A receptor in a patient suffering from Down's syndrome, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt or solvate thereof selected from hemihydrates, hydrates, and alcoholates, wherein said patient is a mammal: ##STR00003## wherein the carbon-carbon bond between 3- and 4- positions in the carbostyril skeleton is a single or a double bond.

2. A method of treating a disorder of he central nervous system associated with the 5-HT.sub.1A receptor in a patient suffering from Down's syndrome, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound, or a pharmaceutically acceptable salt or solvate thereof selected from hemihydrates, hydrates, and alcoholates, wherein said patient is a mammal and wherein the carbostyril compound is 7{4 [4(2,3 dichlorophenyl) 1-piperazinyl]butoxy}-3,4 dihydrocarbostyril.

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