Details for Patent: 8,653,140

Title:	Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
Abstract:	Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
Inventor(s):	Graeber; Michael (Lawrenceville, NJ), Czernielewski; Janusz (Biot, FR)
Assignee:	Galderma Research & Development (Biot, FR)
Filing Date:	May 18, 2012
Application Number:	13/475,827
Claims:	1. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or pharmaceutically acceptable salt thereof relative to the total weight of the composition, effective for the treatment of acne, formulated into a topically applicable, pharmaceutically acceptable medium therefor, with the proviso that when the composition is formulated as a topically applicable gel, it is an aqueous gel comprising at least one carbomer gelling agent. 2. The topically applicable pharmaceutical composition as defined by claim 1, comprising a topically applicable aqueous gel, or a cream or a lotion. 3. The topically applicable pharmaceutical composition as defined by claim 1, comprising an ointment, cream, milk, pomade, powder, impregnated pad, solution, aqueous gel, spray, lotion, patch, hydrogel, or suspension of microspheres or nanospheres of lipid or polymeric vesicles. 4. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) relative to the total weight of the composition, effective for the treatment of acne, formulated as a topically applicable aqueous gel further comprising: Carbomer 940, Disodium edetate, Methyl paraben, Poloxamer 124, Propylene glycol, Sodium hydroxide, and Purified water. 5. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) relative to the total weight of the composition, effective for the treatment of acne, formulated into a topically applicable, pharmaceutically acceptable medium therefor, said composition being in the form of a topically applicable, pharmaceutically acceptable aqueous gel comprising at least one carbomer gelling agent. 6. The topically applicable pharmaceutical composition as defined by claim 5, said composition comprising one or more ingredients selected from the group consisting of carbomer 940 and propylene glycol. 7. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2 naphthoic acid (adapalene) or pharmaceutically acceptable salt thereof relative to the total weight of the composition, effective for the treatment of acne, formulated into a topically applicable, pharmaceutically acceptable medium therefor, said composition being in the form of a topically applicable, pharmaceutically acceptable cream. 8. The topically applicable pharmaceutical composition as defined by claim 7, said composition comprising one or more ingredients selected from the group consisting of perhydrosqualene, cyclomethicone, PEG-20 methyl glucose sequistearate and methyl glucose sequistearate. 9. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid or pharmaceutically acceptable salt thereof relative to the total weight of the composition, effective for the treatment of acne, formulated into a topically applicable, pharmaceutically acceptable medium therefor, said composition being in the form of a topically applicable, pharmaceutically acceptable polyethylene glycol-based alcoholic lotion. 10. The topically applicable pharmaceutical composition as defined by claim 5, further comprising inert additives or combinations of inert additives, said additives being selected from the group consisting of: wetting agents; flavor enhancers; preserving agents; stabilizers; moisture regulators; pH regulators; osmotic pressure modifiers; emulsifiers; UV-A and UV-B screening agents; and antioxidants. 11. The topically applicable pharmaceutical composition as defined by claim 7, further comprising inert additives or combinations of inert additives, said additives being selected from the group consisting of: wetting agents; flavor enhancers; preserving agents; stabilizers; moisture regulators; pH regulators; osmotic pressure modifiers; emulsifiers; UV-A and UV-B screening agents; and antioxidants. 12. The topically applicable pharmaceutical composition as defined by claim 9, further comprising inert additives or combinations of inert additives, said additives being selected from the group consisting of: wetting agents; flavor enhancers; preserving agents; stabilizers; moisture regulators; pH regulators; osmotic pressure modifiers; emulsifiers; UV-A and UV-B screening agents; and antioxidants. 13. A topically applicable pharmaceutical composition comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or pharmaceutically acceptable salt thereof, relative to the total weight of the composition, effective for the treatment of acne, formulated into a topically applicable, pharmaceutically acceptable vehicle therefor, said composition being in the form of a topically applicable, pharmaceutically acceptable aqueous gel comprising at least one carbomer gelling agent.