Details for Patent: 8,618,166

Title:	Methods of treating mixed dyslipidemia
Abstract:	The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
Inventor(s):	Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT), Manku; Mehar (England, GB)
Assignee:	Amarin Pharmaceuticals Ireland Limited (Dublin, IE)
Filing Date:	Jul 02, 2012
Application Number:	13/540,319
Claims:	1. A method of treating mixed dyslipidemia in a subject on statin therapy comprising, administering to the subject 4 capsules each comprising about 1 g of ethyl eicosapentaenoate daily effective to reduce fasting triglycerides and LDL-C relative to subjects having mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 2. The method of claim 1, wherein said administering step reduces fasting triglycerides by at least 10% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 3. The method of claim 1, wherein said administering step reduces fasting triglycerides by at least 15% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 4. The method of claim 1, wherein said administering step reduces fasting triglycerides by at least 20% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 5. The method of claim 1, wherein said administering step reduces fasting triglycerides by at least 25% and LDL-C by at least 5% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 6. The method of claim 1, wherein said administering step reduces fasting apolipoprotein B relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 7. The method of claim 1, wherein said administering step reduces fasting apolipoprotein B by at least 5% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 8. The method of claim 1, wherein said administering step reduces fasting VLDL-C relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 9. The method of claim 1, wherein said administering step reduces fasting VLDL-C by at least 15% relative to subjects with mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 10. The method of claim 1, wherein the statin is selected from lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, fluvastatin, atorvastatin and simvastatin. 11. A method of treating mixed dyslipidemia in a subject on statin therapy comprising, administering to the subject 4 capsules each comprising about 900 mg of ethyl eicosapentaenoate daily effective to reduce fasting triglycerides and LDL-C relative to subjects having mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 12. A method of treating mixed dyslipidemia in a subject on statin therapy comprising, administering to the subject 4 capsules each comprising about 925 mg or about 950 mg of ethyl eicosapentaenoate daily effective to reduce fasting triglycerides and LDL-C relative to subjects having mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate. 13. A method of treating mixed dyslipidemia in a subject on statin therapy comprising, administering to the subject 4 capsules each comprising about 975 mg of ethyl eicosapentaenoate daily effective to reduce fasting triglycerides and LDL-C relative to subjects having mixed dyslipidemia who are receiving a statin without said ethyl eicosapentaenoate.