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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Federal Trade Commission
Boehringer Ingelheim
Express Scripts
Queensland Health

Generated: April 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,598,215

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Title:Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
Abstract: Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.
Inventor(s): Lee; Francis Y. F. (Yardley, PA)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:Jul 23, 2009
Application Number:12/508,100
Claims:1. A method for treating cancer selected from metastatic breast cancer, lung cancer, pancreatic cancer, ovarian cancer, prostate cancer, colon cancer, and small cell lung cancer, which comprises administering to a mammal a combination therapy comprising a dosage unit of Compound (1), having the formula, ##STR00022## or a stereoisomer of Compound (1), and a dosage unit of bevacizumab, wherein the combination therapy will provide a greater anti-cancer effect than the effect obtainable with either the dosage unit of Compound (1) or bevacizumab alone.

2. The method of claim 1 wherein the cancer is refractory, resistant, or sensitive to taxane treatment.

3. The method of claim 1, wherein bevacizumab is administered following the administration of Compound (1).

4. The method according to claim 1, wherein bevacizumab is administered before the administration of Compound (1).

5. The method according to claim 1, wherein bevacizumab is administered substantially simultaneously with the administration of Compound (1).

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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Johnson and Johnson
Argus Health
Fish and Richardson
Queensland Health

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