|Title:||Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases|
|Abstract:|| Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.|
|Inventor(s):|| Lee; Francis Y. F. (Yardley, PA) |
|Assignee:|| Bristol-Myers Squibb Company (Princeton, NJ) |
|Filing Date:||Jul 23, 2009|
|Claims:||1. A method for treating cancer selected from metastatic breast cancer, lung cancer, pancreatic cancer, ovarian cancer, prostate cancer, colon cancer, and small cell lung cancer, which comprises administering to a mammal a combination therapy comprising a dosage unit of Compound (1), having the formula, ##STR00022## or a stereoisomer of Compound (1), and a dosage unit of bevacizumab, wherein the combination therapy will provide a greater anti-cancer effect than the effect obtainable with either the dosage unit of Compound (1) or bevacizumab alone. |
2. The method of claim 1 wherein the cancer is refractory, resistant, or sensitive to taxane treatment.
3. The method of claim 1, wherein bevacizumab is administered following the administration of Compound (1).
4. The method according to claim 1, wherein bevacizumab is administered before the administration of Compound (1).
5. The method according to claim 1, wherein bevacizumab is administered substantially simultaneously with the administration of Compound (1).