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Generated: October 15, 2018

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Details for Patent: 8,536,327

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Title:Epothilone derivatives
Abstract: The present invention relates to compounds of the formula ##STR00001## where the variables are as defined in the disclosure.
Inventor(s): Vite; Gregory D. (Titusville, NJ), Kim; Soong-Hoon (Lawrenceville, NJ), Borzilleri; Robert M. (Lawrenceville, NJ), Johnson; James A. (Lawrenceville, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:Jun 15, 2007
Application Number:11/763,636
Claims:1. A compound having the formula V, ##STR00055## wherein G is bicycloheteroaryl; R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are selected from the group consisting of H, alkyl, substituted alkyl, and aryl; and R.sub.8 is H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo.

2. A compound according to claim 1 wherein G is bicycloheteroaryl selected from benzothiazolyl, benzoxazolyl, benzothienyl, quinuclidinyl, quinolinyl, quinolinyl-N-oxide, tetrahydroisoquinolinyl, isoquinolinyl, benzimidazolyl, benzopyranyl, indolizinyl, benzofuryl, chromonyl, coumarinyl, cinnolinyl, quinoxalinyl, indazolyl, pyrrolopyridyl, furo[2,3-c]pyridinyl, furo[3,1-13]pyridinyl, furo[2,3-b]pyridinyl, dihydroisoindolyl, 3,4-dihydro-4-oxo-quinazolinyl, benzisothiazolyl, benzisoxazolyl, benzodiazinyl, benzofurazanyl, benzothiopyranyl, benzotriazolyl, benzpyrazolyl, dihydrobenzofuryl, dihydrobenzothienyl, dihydrobenzothiopyranyl, dihydrobenzothiopyranyl sulfone, dihydrobenzopyranyl, indolinyl, isochromanyl, isoindolinyl, naphthyridinyl, phthalazinyl, piperonyl, purinyl, pyridopyridyl, quinazolinyl, tetrahydroquinolinyl, thienofuryl, thienopyridyl, and thienothienyl.

3. A compound according to claim 2 wherein G is benzothiazolyl.

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