Details for Patent: 8,536,167

Title:	Methods for treating ophthalmic, otic, or nasal infections
Abstract:	The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
Inventor(s):	Stroman; David W. (Irving, TX), Chowhan; Masood A. (Arlington, TX), Appell; Kenneth C. (Burleson, TX)
Assignee:	Alcon Research, Ltd. (Fort Worth, TX)
Filing Date:	Jul 02, 2010
Application Number:	12/829,973
Claims:	1. A method for treating an ophthalmic, otic, or nasal infection comprising: treating the infection with a pharmaceutically effective amount of a composition comprising finafloxacin at a concentration of 0.1 to 1.0 w/v %. 2. A method according to claim 1 wherein said infection is a nasal infection. 3. A method according to claim 1 wherein said infection is acute otitis externa or acute otitis media with tympanostomy tubes. 4. A method according to claim 1 wherein said composition comprises finafloxacin or a pharmaceutically acceptable salt thereof at a concentration of 0.1 to 0.5 w/v %. 5. A method according to claim 1 wherein said composition comprises finafloxacin or a pharmaceutically acceptable salt thereof at a concentration of 0.3 to 0.4 w/v %. 6. A method according to claim 1, said composition having a pH of 5.0 to 7.5. 7. A method according to claim 1, said composition having a pH of 5.0 to 6.0. 8. A method according to claim 1, said composition further comprising an anti-inflammatory agent. 9. A method according to claim 8 wherein said anti-inflammatory agent is dexamethasone. 10. A method according to claim 1 wherein said infection is an otic infection.