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Details for Patent: 8,455,376

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Details for Patent: 8,455,376

Title:Adhesive preparation
Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC.sub.0-24 ranging from 3.0 to 60.0 nghr/mL in terms of a mean.+-.standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC.sub.0-24 ranging from 5000 to 13000 nghr/mL in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m.sup.2 and a contact area is 280 cm.sup.2.
Inventor(s): Tsuruda; Kiyomi (Tosu, JP), Yamasoto; Shinji (Tosu, JP), Shoho; Kouki (Tosu, JP), Nakanishi; Masaru (Tsukuba, JP)
Assignee: Hisamitsu Pharmaceutical Co., Inc. (Tosu-Shi, Saga, JP)
Filing Date:Aug 01, 2007
Application Number:12/227,066
Claims:1. An adhesive preparation, comprising: a stretchable support comprising a crimped interlock woven fabric; and an adhesive layer laminated on at least one side of the support, the adhesive layer consisting of methyl salicylate present of an amount of from 10% to 15% by mass with respect to the total mass of the adhesive layer, I-menthol present in an amount of from 3.0 to 4.5% by mass with respect to the total mass of the adhesive layer, a thermoplastic elastomer of both polyisobutylene and styrene-isoprene-styrene block copolymer present in an amount of from 35% to 40% by mass with respect to the total mass of the adhesive layer, liquid paraffin present in an amount of from 20 to 35% by mass with respect to the total mass of the adhesive layer, and alicyclic saturated hydrocarbon resin present in an amount of from 17% by mass to 20.5% by mass with respect to the total mass of the adhesive layer, the whole adhesive preparation having a moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and the adhesive preparation being configured such that the methyl salicylate yields a plasma AUC.sub.0-24 ranging from 3.0 to 60.0 nghr/mL in terms of a mean.+-.standard deviation, and salicylic acid as a metabolite of the methyl salicylate yields a plasma AUC.sub.0-24 ranging from 5000 to 13000 nghr/mL in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m.sup.2 and a contact area is 280 cm.sup.2.

2. The adhesive preparation according to claim 1, wherein the woven fabric has a weight of 80 to 150 g/m.sup.2.

3. The adhesive preparation according to claim 1, wherein the I-menthol yields a plasma AUC.sub.0-24 ranging from 30.0 to 130.0 nghr/mL in terms of a mean.+-.standard deviation and a plasma C.sub.max ranging from 5.0 to 20.0 ng/mL in term of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m.sup.2 and a contact area is 280 cm.sup.2.

4. The adhesive preparation according to claim 1, wherein the stretchable support has a longitudinal modulus of from 2 to 12 N/5 cm and a lateral modulus of from 2 to 8 N/5 cm.
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